2. Academic Validation
  3. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors

Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors

  • Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9. doi: 10.1016/j.bmcl.2012.10.084.
Yoshito Terao 1,  Hideo Suzuki,  Masato Yoshikawa,  Hiroaki Yashiro,  Shiro Takekawa,  Yasushi Fujitani,  Kengo Okada,  Yoshihisa Inoue,  Yoshio Yamamoto,  Hideyuki Nakagawa,  Shuhei Yao,  Tomohiro Kawamoto,  Osamu Uchikawa
Affiliations

Affiliation

  • 1 Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. yoshito.terao@takeda.com
PMID: 23147077 DOI: 10.1016/j.bmcl.2012.10.084
Abstract

Imidazo[1,2-a]pyridine derivatives were designed, synthesized, and evaluated as inhibitors of the Apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole derivative that was discovered from high-throughput screening of our compound library. As a result, we identified potent, selective, and orally bioavailable ASK1 inhibitors for wide range of therapeutic targets.

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