2. Academic Validation
  3. Five new degraded diterpenoids from Trigonostemon xyphophylloides

Five new degraded diterpenoids from Trigonostemon xyphophylloides

  • Bioorg Med Chem Lett. 2013 Oct 15;23(20):5748-51. doi: 10.1016/j.bmcl.2013.01.112.
Biao Yang 1,  Guang-Ying Chen,  Xiao-Ping Song,  Liu-Qing Yang,  Xiang-Yang Wu,  Chang-Ri Han,  Wen-Hao Chen,  Bing-Yan Zou,  Xiao-Man Li
Affiliations

Affiliation

  • 1 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China; Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
PMID: 23999045 DOI: 10.1016/j.bmcl.2013.01.112
Abstract

Five new degraded Diterpenoids trigoxyphins J-N (1-5), among them trigoxyphins K and L have a novel carbon skeleton, together with four known analogues (6-9) have been obtained from the ethanol extract of the twigs of Trigonostemon xyphophylloides. Compounds 1-5 were evaluated for their cytotoxic activity in vitro against three human tumor cell lines by MTT assay. The results exhibited that Trigoxyphin N (5) showed moderate cytotoxicities against SPC-A-1 and SGC-7901 Cancer cell lines.

Keywords

Chemical constituents; Cytotoxic activities; Trigonostemon; Trigonostemon xyphophylloide.

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