2. Academic Validation
  3. Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy

Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy

  • Theranostics. 2014 Jan 15;4(3):229-39. doi: 10.7150/thno.8070.
Pengfei Rong 1,  Kai Yang 2,  Avinash Srivastan 3,  Dale O Kiesewetter 3,  Xuyi Yue 4,  Fu Wang 3,  Liming Nie 4,  Ashwinkumar Bhirde 3,  Zhe Wang 3,  Zhuang Liu 5,  Gang Niu 3,  Wei Wang 6,  Xiaoyuan Chen 3
Affiliations

Affiliations

  • 1 1. Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China ; 2. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States ; 3. State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan, 410083, China.
  • 2 2. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States ; 4. Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China.
  • 3 2. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States.
  • 4 2. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, United States ; 5. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China.
  • 5 4. Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China.
  • 6 1. Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
PMID: 24505232 DOI: 10.7150/thno.8070
Abstract

Graphene, a 2-dimensional carbon nanomaterial, has attracted wide attention in biomedical applications, owing to its intrinsic physical and chemical properties. In this work, a photosensitizer molecule, 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha (HPPH or Photochlor®), is loaded onto polyethylene glycol (PEG)-functionalized graphene oxide (GO) via supramolecular π-π stacking. The obtained GO-PEG-HPPH complex shows high HPPH loading efficiency. The in vivo distribution and delivery were tracked by fluorescence imaging as well as positron emission tomography (PET) after radiolabeling of HPPH with (64)Cu. Compared with free HPPH, GO-PEG-HPPH offers dramatically improved photodynamic Cancer cell killing efficacy due to the increased tumor delivery of HPPH. Our study identifies a role for graphene as a carrier of PDT agents to improve PDT efficacy and increase long-term survival following treatment.

Keywords

Graphene oxide; HPPH; optical imaging.; photodynamic therapy; positron emission tomography.

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