2. Academic Validation
  3. Red Si-rhodamine drug conjugates enable imaging in GFP cells

Red Si-rhodamine drug conjugates enable imaging in GFP cells

  • Chem Commun (Camb). 2014 May 4;50(34):4504-7. doi: 10.1039/c4cc00144c.
Eunha Kim 1,  Katherine S Yang,  Randy J Giedt,  Ralph Weissleder
Affiliations

Affiliation

  • 1 Center for Systems Biology, Massachusettes General Hospital/Harvard Medical School, 185 Cambridge St, Boston, MA 02114, USA. rweissleder@mgh.harvard.edu.
PMID: 24663433 DOI: 10.1039/c4cc00144c
Abstract

Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not Others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.

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