2. Academic Validation
  3. A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana

A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana

  • Nat Chem Biol. 2014 Oct;10(10):830-6. doi: 10.1038/nchembio.1591.
Christian Meesters 1,  Timon Mönig 2,  Julian Oeljeklaus 2,  Daniel Krahn 2,  Corey S Westfall 3,  Bettina Hause 4,  Joseph M Jez 3,  Markus Kaiser 2,  Erich Kombrink 5
Affiliations

Affiliations

  • 1 1] Chemical Biology Laboratory, Max Planck Institute for Plant Breeding Research, Köln, Germany. [2] Center for Medical Biotechnology, Department of Chemical Biology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.
  • 2 Center for Medical Biotechnology, Department of Chemical Biology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.
  • 3 Department of Biology, Washington University, St. Louis, Missouri, USA.
  • 4 Department of Cell and Metabolic Biology, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.
  • 5 Chemical Biology Laboratory, Max Planck Institute for Plant Breeding Research, Köln, Germany.
PMID: 25129030 DOI: 10.1038/nchembio.1591
Abstract

Jasmonates are lipid-derived plant Hormones that regulate plant defenses and numerous developmental processes. Although the biosynthesis and molecular function of the most active form of the hormone, (+)-7-iso-jasmonoyl-L-isoleucine (JA-Ile), have been unraveled, it remains poorly understood how the diversity of bioactive jasmonates regulates such a multitude of plant responses. Bioactive analogs have been used as chemical tools to interrogate the diverse and dynamic processes of jasmonate action. By contrast, small molecules impairing jasmonate functions are currently unknown. Here, we report on jarin-1 as what is to our knowledge the first small-molecule inhibitor of jasmonate responses that was identified in a chemical screen using Arabidopsis thaliana. Jarin-1 impairs the activity of JA-Ile synthetase, thereby preventing the synthesis of the active hormone, JA-Ile, whereas closely related enzymes are not affected. Thus, jarin-1 may serve as a useful chemical tool in search for missing regulatory components and further dissection of the complex jasmonate signaling networks.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-115521
    99.33%, JAR1 抑制剂
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