1. Academic Validation
  2. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology

Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology

  • Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58. doi: 10.1016/j.cytogfr.2015.07.006.
Heike M Hermanns 1
Affiliations

Affiliation

  • 1 University Hospital Würzburg, Department of Internal Medicine II, Hepatology Research Laboratory, Grombühlstr. 12, 97080 Würzburg, Germany. Electronic address: Hermanns_H@ukw.de.
Abstract

Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM Receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respective receptor complexes they signal mainly via the JAK/STAT pathway. Besides sharing many biochemical properties, both display divergent physiological functions. This review summarizes aspects of cytokine transcription and biosynthesis, cytokine-receptor interactions, cross-species activities, signal transduction and physiology delineated from recent findings in genetic mouse models for both cytokines, OSM and IL-31.

Keywords

Cytokines; Inflammation; Interleukin-31; Oncostatin M; Signal transduction.

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