1. Academic Validation
  2. New clerodane diterpenoids from the roots of Polyalthia laui

New clerodane diterpenoids from the roots of Polyalthia laui

  • Fitoterapia. 2016 Jun;111:36-41. doi: 10.1016/j.fitote.2016.03.017.
Zhang-Xin Yu 1 Yan-Hui Fu 1 Guang-Ying Chen 1 Xiao-Ping Song 2 Chang-Ri Han 3 Xiao-Bao Li 1 Xin-Ming Song 1 Ai-Zhen Wu 1 Shi-Chen Chen 1
Affiliations

Affiliations

  • 1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China.
  • 2 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China. Electronic address: sxp628@126.com.
  • 3 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, PR China. Electronic address: hchr116@126.com.
Abstract

Five new clerodane Diterpenoids, polylauiester A (1), (4→2)-abeo-2,13-diformyl-cleroda-2,12E-dien-14-oic acid (2) and polylauiamides B-D (3-5), together with 11 known clerodane Diterpenoids (6-16), were isolated from the roots of Polyalthia laui. Among them, polylauiester A (1) represents the first example of a novel norclerodane diterpenoid only containing 17 carbon atoms on the carbon skeleton, and polylauiamide B (3) is an unusual diterpenoid with a p-substituted benzene ring as a substituent. Their structures were elucidated by extensive spectroscopic methods, and the relative configuration of polylauiamide B (3) was further confirmed by the single crystal X-ray diffraction method. Biological evaluation of new compounds against human Hela, MCF-7 and A549 human Cancer cell lines showed that all compounds displayed weak cytotoxicities against various human Cancer cell lines in the range of IC50 at 25.01-39.31μM.

Keywords

Clerodane diterpenoids; Cytotoxicity; Polyalthia laui; Polylauiamides B–D; Polylauiester A.

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