2. Academic Validation
  3. The role of IL-29 in immunity and cancer

The role of IL-29 in immunity and cancer

  • Crit Rev Oncol Hematol. 2016 Oct;106:91-8. doi: 10.1016/j.critrevonc.2016.08.002.
Noah E Kelm 1,  Ziwen Zhu 2,  Vivi A Ding 1,  Huaping Xiao 3,  Mark R Wakefield 2,  Qian Bai 2,  Yujiang Fang 4
Affiliations

Affiliations

  • 1 Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, United States.
  • 2 Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, United States.
  • 3 Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, United States; The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, China.
  • 4 Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA 50312, United States; Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, United States. Electronic address: yujiang.fang@dmu.edu.
PMID: 27637354 DOI: 10.1016/j.critrevonc.2016.08.002
Abstract

Interleukin-29 (IL-29) is a new member of the recently discovered interferon λ (IFNλ) family. It is produced predominantly by maturing dendritic cells and macrophages. It has been implicated in numerous immunological responses and has shown Antiviral activity similar to the Type I interferons, although its target cell population is more limited than the Type I interferons. In recent years, the role of IL-29 in the pathogenesis of various cancers has also been extensively studied. In this review, we will discuss the recent advances of IL-29 in immunological processes and the pathogenesis of various Cancer.

Keywords

Cancer; Cytokine; IL-29; Immune response.

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