2. Academic Validation
  3. Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex

Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex

  • Biosci Biotechnol Biochem. 2017 Jun;81(6):1106-1113. doi: 10.1080/09168451.2017.1300517.
Ying Huang 1,  Osamu Ohno 2,  Kiyotake Suenaga 3,  Kenji Miyamoto 1
Affiliations

Affiliations

  • 1 a Department of Biosciences & Informatics , Keio University , Yokohama , Japan.
  • 2 b Department of Chemistry and Life Science , School of Advanced Engineering, Kogakuin University , Hachioji , Japan.
  • 3 c Department of Chemistry , Keio University , Yokohama , Japan.
PMID: 28317437 DOI: 10.1080/09168451.2017.1300517
Abstract

Ninety samples from the extracts of Plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an active ingredient from the root of moutan cortex, which showed the strongest activity. In addition, our data indicated that PFG was cytotoxic and induced Apoptosis selectively in the Cancer cell lines. These effects were cancelled by the addition of Caspase Inhibitor Z-VAD-FMK, suggesting that it was mediated by Caspase-3 activation.

Keywords

Paeonia suffruticosa Andr.; Paeoniflorigenone; antiproliferative activity; apoptosis; caspase-3 activation.

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