2. Academic Validation
  3. New Cytotoxic Alkylated Chalcones from Fatoua villosa

New Cytotoxic Alkylated Chalcones from Fatoua villosa

  • Chem Biodivers. 2017 Jun;14(6). doi: 10.1002/cbdv.201700076.
Shi-Yun Su 1,  Jing-Jing Xue 1,  Guang-Yu Yang 2,  Chun Lei 1,  Ai-Jun Hou 1
Affiliations

Affiliations

  • 1 Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
  • 2 Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., Kunming, 650231, P. R. China.
PMID: 28371315 DOI: 10.1002/cbdv.201700076
Abstract

Three new alkylated Chalcones, villosins A - C (1 - 3), five known analogues, together with ten known Coumarins, were isolated from Fatoua villosa. The structures of the new compounds were elucidated by extensive spectroscopic analysis, including 1D-, 2D-NMR, and MS data. Compounds 1 - 3 showed cytotoxicity against five kinds of human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) with IC50 values ranging from 1.4 ± 0.1 to 5.7 ± 0.3 μm.

Keywords

Fatoua villosa; Alkylated chalcone; Coumarin; Cytotoxic activities; Villosin.

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