2. Academic Validation
  3. Protective Effect of 18 β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats

Protective Effect of 18 β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats

  • Evid Based Complement Alternat Med. 2017;2017:3470320. doi: 10.1155/2017/3470320.
Guanghua Yang 1,  Lan Wang 2,  Xiuting Yu 2,  Yanfeng Huang 1,  Chang Qu 1,  Zhenbiao Zhang 1,  Dandan Luo 1,  Ji Lin 1 2,  Lian Zhou 1,  Ziren Su 1 3 4,  Xiaojun Zhang 1,  Haiming Chen 5 6
Affiliations

Affiliations

  • 1 School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • 2 The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
  • 3 Guangdong Provincial Key Laboratory of New Chinese Medicinals Development and Research, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • 4 Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan 523808, China.
  • 5 Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
  • 6 Postdoctoral Programme, Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
PMID: 28572827 DOI: 10.1155/2017/3470320
Abstract

Triptolide (TP) is the major active component of Tripterygium wilfordii Hook F (TWHF) and possesses multiple pharmacological effects. However, hepatotoxicity of TP which is one of the toxic properties slows its progression in clinical application. 18β-Glycyrrhetinic acid (GA) is the main bioactive ingredient of Licorice (Glycyrrhiza glabra L.), a herbal medicine famous for its detoxification. This study aims to investigate whether GA possesses protective effect against TP-induced hepatotoxicity in rats. TP interference markedly elevated serum levels of ALT, AST, and ALP, caused evident liver histopathological changes, and elevated hepatic TNF-α, IL-6, IL-1β, and IFN-γ as well as nuclear translocation of NF-κB. TP also significantly elevated liver MDA and declined hepatic activities of SOD, CAT, and GSH-Px. Assay of TUNEL and Apoptosis proteins (Bax, Bcl-2, and active Caspase-3) showed that TP induced severe hepatocellular Apoptosis. In contrast, low-dose GA (50 mg/kg) significantly reversed TP-induced changes above. However, high-dose GA (100 mg/kg) had no such effect. Overall, these findings indicated that low-dose GA but not high-dose GA exhibited a protective effect against TP-induced hepatotoxicity in rats by anti-inflammation, antioxidation, and antiapoptosis, which suggests that the doses of GA/Licorice should be carefully considered when used together with TWHF or TWHF preparations.

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