1. Academic Validation
  2. Triclosan and triclocarban exposure and thyroid function during pregnancy-A randomized intervention

Triclosan and triclocarban exposure and thyroid function during pregnancy-A randomized intervention

  • Reprod Toxicol. 2017 Dec;74:143-149. doi: 10.1016/j.reprotox.2017.09.005.
Catherine Ley 1 Lauren Pischel 2 Julie Parsonnet 3
Affiliations

Affiliations

  • 1 Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, United States. Electronic address: cley@stanford.edu.
  • 2 Division of Epidemiology, Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305, United States.
  • 3 Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, United States; Division of Epidemiology, Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305, United States.
Abstract

Triclosan and triclocarban (TCs) are broad-spectrum microbicides found in household and personal wash products. We sought to determine whether TC exposure from wash products or urinary triclosan level modified thyroid function during pregnancy or anthropometric measurements at birth. A randomized intervention of wash products with or without TCs, including toothpaste, enrolled pregnant women from 20 weeks' gestation. Urinary triclosan, TSH, T4 and T3 were assessed at enrollment, 36weeks' gestation and/or post-delivery; anthropometric measures at birth were ascertained from medical records. 78 and 76 mothers were assigned to the TC-containing and no-TC-containing product arms, respectively. No differences were observed in any thyroid function measure at any time point or in any anthropometric measurement at birth between either exposure arms or lowest and highest urinary triclosan quartile groups. TCs from wash products, primarily liquid and bar soaps, did not affect thyroid function measures during pregnancy or babies' anthropometric measures at delivery.

Keywords

Anthropometry; Pregnancy; Randomized intervention; Thyroid function; Triclocarban; Triclosan.

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