2. Academic Validation
  3. Cytotoxic Triterpenoids from Roots of Actinidia chinensis

Cytotoxic Triterpenoids from Roots of Actinidia chinensis

  • Chem Biodivers. 2018 Feb;15(2). doi: 10.1002/cbdv.201700454.
Liu-Bin Wei 1,  Si-Yuan Ma 2,  Hong-Xing Liu 2 3,  Chu-Sheng Huang 2 3,  Na Liao 1
Affiliations

Affiliations

  • 1 College of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, P. R. China.
  • 2 College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning, 530001, P. R. China.
  • 3 State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541000, P. R. China.
PMID: 29164821 DOI: 10.1002/cbdv.201700454
Abstract

Phytochmical investigation of roots of Actinidia chinensisPlanch. led to the isolation triterpenoids 1 - 16, including a new compound 2α,3α,23,24-tetrahydroxyursa-12,20(30)-dien-28-oic acid (1). Their structures were identified on the basis of spectroscopic analysis, including 1D- and 2D-NMR, HR-ESI mass spectrometry, and by comparison with the literatures. The cytotoxicities of triterpenoids 1 - 16 against a panel of cultured human Cancer cell lines (HepG2, A549, MCF-7, SK-OV-3, and HeLa) were evaluated. The new compound 1 exhibited moderate antitumor activities with IC50 values of 19.62 ± 0.81, 18.86 ± 1.56, 45.94 ± 3.62, 62.41 ± 2.29, and 28.74 ± 1.07 μm, respectively. The experiment data might be available to explain the use of roots of A. chinensis to treat various cancers in traditional Chinese medicine.

Keywords

Actinidia chinensis; Actinidiaceae; cytotoxic activities; triterpenoid.

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