2. Academic Validation
  3. The GDNF Family: A Role in Cancer?

The GDNF Family: A Role in Cancer?

  • Neoplasia. 2018 Jan;20(1):99-117. doi: 10.1016/j.neo.2017.10.010.
Graeme C Fielder 1,  Teresa Wen-Shan Yang 1,  Mahalakshmi Razdan 2,  Yan Li 2,  Jun Lu 2,  Jo K Perry 3,  Peter E Lobie 4,  Dong-Xu Liu 5
Affiliations

Affiliations

  • 1 University of Auckland, Auckland, New Zealand.
  • 2 The Centre for Biomedical and Chemical Sciences, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.
  • 3 Liggins Institute, University of Auckland, Auckland, New Zealand.
  • 4 Cancer Science Institute of Singapore and Department of Pharmacology, National University of Singapore, Singapore; Tsinghua Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, Guangdong, P. R. China.
  • 5 The Centre for Biomedical and Chemical Sciences, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand. Electronic address: dong-xu.liu@aut.ac.nz.
PMID: 29245123 DOI: 10.1016/j.neo.2017.10.010
Abstract

The glial cell line-derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of GDNF, Neurturin, Artemin, and persephin plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis. Here we review our current understanding of GFL biology, and supported by recent progress in the area, we examine their emerging role in endocrine-related and other non-hormone-dependent solid neoplasms. The ability of GFLs to elicit actions that resemble those perturbed in an oncogenic phenotype, alongside mounting evidence of GFL involvement in tumor progression, presents novel opportunities for therapeutic intervention.

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