2. Academic Validation
  3. Germacrane-Type Sesquiterpenoids with Antiproliferative Activities from Eupatorium chinense

Germacrane-Type Sesquiterpenoids with Antiproliferative Activities from Eupatorium chinense

  • J Nat Prod. 2018 Jan 26;81(1):85-91. doi: 10.1021/acs.jnatprod.7b00693.
Xiaoqin Yu 1 2,  Qingqing Zhang 1,  Li Tian 1,  Zhiyong Guo 1,  Chengxiong Liu 1,  Jianfeng Chen 1,  Weaam Ebrahim 2 3,  Zhen Liu 2,  Peter Proksch 2,  Kun Zou 1
Affiliations

Affiliations

  • 1 Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang 443002, People's Republic of China.
  • 2 Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Duesseldorf , 40225 Duesseldorf, Germany.
  • 3 Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University , Mansoura 35516, Egypt.
PMID: 29280632 DOI: 10.1021/acs.jnatprod.7b00693
Abstract

Ten new germacrane-type sesquiterpenoids (1-10) were isolated from a whole plant extract of Eupatorium chinense. The structures were elucidated by analysis of their NMR and MS data as well as by comparison with literature values. The absolute configuration of eupachinsin A (1) was determined by single-crystal X-ray diffraction analysis. Compounds 3 and 4 exhibited cytotoxicity against a human breast Cancer cell line (MDA-MB-231), with IC50 values of 0.8 and 3.4 μM, respectively. In addition, compounds 3-5 showed cytotoxicity against the human hepatocellular carcinoma cell line (HepG2), with IC50 values ranging from 3.6 to 7.6 μM.

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