2. Academic Validation
  3. Mouse models for the analysis of gonadotropin secretion and action

Mouse models for the analysis of gonadotropin secretion and action

  • Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):219-239. doi: 10.1016/j.beem.2018.03.006.
Sara Babcock Gilbert 1,  Allyson K Roof 2,  T Rajendra Kumar 3
Affiliations

Affiliations

  • 1 Division of Reproductive Endocrinology and Infertility, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Division of Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
  • 2 Division of Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
  • 3 Division of Reproductive Endocrinology and Infertility, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Division of Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Electronic address: raj.kumar@ucdenver.edu.
PMID: 29779578 DOI: 10.1016/j.beem.2018.03.006
Abstract

Gonadotropins are pituitary gonadotrope-derived glycoprotein Hormones. They act by binding to G-protein coupled receptors on gonads. Gonadotropins play critical roles in reproduction by regulating both gametogenesis and steroidogenesis. Although biochemical and physiological studies provided a wealth of knowledge, gene manipulation techniques using novel mouse models gave new insights into gonadotropin synthesis, secretion and action. Both gain of function and loss of function mouse models for understanding gonadotropin action in a whole animal context have already been generated. Moreover, recent studies on gonadotropin actions in non-gonadal tissues challenged the central dogma of classical gonadotropin actions in gonads and revealed new signaling pathways in these non-gonadal tissues. In this Chapter, we have discussed our current understanding of gonadotropin synthesis, secretion and action using a variety of genetically engineered mouse models.

Keywords

follicle-stimulating hormone; gonadotrope; luteinizing hormone; ovary; testis; transgenic mice.

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