2. Academic Validation
  3. Total Synthesis of the Neoclerodane Diterpene Salvinorin A via an Intramolecular Diels-Alder Strategy

Total Synthesis of the Neoclerodane Diterpene Salvinorin A via an Intramolecular Diels-Alder Strategy

  • Org Lett. 2018 Jun 1;20(11):3418-3421. doi: 10.1021/acs.orglett.8b01357.
Yuzhou Wang 1,  Peter Metz 1
Affiliations

Affiliation

  • 1 Fakultät Chemie und Lebensmittelchemie, Organische Chemie I , Technische Universität Dresden , Bergstrasse 66 , 01069 Dresden , Germany.
PMID: 29787286 DOI: 10.1021/acs.orglett.8b01357
Abstract

A concise total synthesis of the neoclerodane diterpene salvinorin A from 3-furaldehyde is reported using two highly diastereoselective intramolecular Diels-Alder reactions (IMDA) as the key transformations.

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