2. Academic Validation
  3. Curvulin and Phaeosphaeride A from Paraphoma sp. VIZR 1.46 Isolated from Cirsium arvense as Potential Herbicides

Curvulin and Phaeosphaeride A from Paraphoma sp. VIZR 1.46 Isolated from Cirsium arvense as Potential Herbicides

  • Molecules. 2018 Oct 28;23(11):2795. doi: 10.3390/molecules23112795.
Ekaterina Poluektova 1,  Yuriy Tokarev 2,  Sofia Sokornova 3,  Leonid Chisty 4,  Antonio Evidente 5,  Alexander Berestetskiy 6
Affiliations

Affiliations

  • 1 All-Russian Institute of Plant Protection, Podbelskogo 3, 196608 Pushkin, Russia. e.poluektova@vizr.spb.ru.
  • 2 All-Russian Institute of Plant Protection, Podbelskogo 3, 196608 Pushkin, Russia. ytokarev@vizr.spb.ru.
  • 3 All-Russian Institute of Plant Protection, Podbelskogo 3, 196608 Pushkin, Russia. svsokornova@vizr.spb.ru.
  • 4 Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, p/o Kuz'molovsky, 188663 Saint-Petersburg, Russia. mehrn.q2@gmail.com.
  • 5 Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy. evidente@unina.it.
  • 6 All-Russian Institute of Plant Protection, Podbelskogo 3, 196608 Pushkin, Russia. aberestetskiy@vizr.spb.ru.
PMID: 30373298 DOI: 10.3390/molecules23112795
Abstract

Phoma-like fungi are known as producers of diverse spectrum of secondary metabolites, including phytotoxins. Our bioassays had shown that extracts of Paraphoma sp. VIZR 1.46, a pathogen of Cirsium arvense, are phytotoxic. In this study, two phytotoxically active metabolites were isolated from Paraphoma sp. VIZR 1.46 liquid and solid cultures and identified as curvulin and phaeosphaeride A, respectively. The latter is reported also for the first time as a Fungal phytotoxic product with potential herbicidal activity. Both metabolites were assayed for phytotoxic, antimicrobial and zootoxic activities. Curvulin and phaeosphaeride A were tested on weedy and agrarian Plants, fungi, Gram-positive and Gram-negative bacteria, and on paramecia. Curvulin was shown to be weakly phytotoxic, while phaeosphaeride A caused severe necrotic lesions on all the tested Plants. To evaluate phaeosphaeride A's herbicidal efficacy, the phytotoxic activity of this compound in combination with five different adjuvants was studied. Hasten at 0.1% (v/v) was found to be the most potent and compatible adjuvant, and its combination with 0.5% (v/v) semi-purified extract of Paraphoma sp. VIZR 1.46 solid culture exhibited maximum damage to C. arvense Plants. These findings may offer significant importance for further investigation of herbicidal potential of phaeosphaeride A and possibly in devising new herbicide of natural origin.

Keywords

Paraphoma sp. VIZR 1.46; curvulin; herbicidal potential; phaeosphaeride A; phytotoxins.

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