2. Academic Validation
  3. Oxetane-containing metabolites: origin, structures, and biological activities

Oxetane-containing metabolites: origin, structures, and biological activities

  • Appl Microbiol Biotechnol. 2019 Mar;103(6):2449-2467. doi: 10.1007/s00253-018-09576-z.
Vera Vil 1,  Alexander O Terent'ev 1,  Abed Al Aziz Al Quntar 2,  Tatyana A Gloriozova 3,  Nick Savidov 4,  Valery M Dembitsky 5 6 7
Affiliations

Affiliations

  • 1 N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia, 119991.
  • 2 Department of Material Engineering, Faculty of Engineering, Al Quds University, Abu Dies, Palestinian Authority, Jerusalem, Israel.
  • 3 Institute of Biomedical Chemistry, Moscow, Russia, 119121.
  • 4 Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge, AB, T1K 1L6, Canada.
  • 5 N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia, 119991. valeryde@imb.dvo.ru.
  • 6 Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge, AB, T1K 1L6, Canada. valeryde@imb.dvo.ru.
  • 7 Biochemical Lab, National Scientific Center of Marine Biology, 17 Palchevsky Str, Vladivostok, Russia, 690041. valeryde@imb.dvo.ru.
PMID: 30610285 DOI: 10.1007/s00253-018-09576-z
Abstract

Cyclobutanes containing one oxygen atom in a molecule are called oxetane-containing compounds (OCC). More than 600 different OCC are found in nature; they are produced by Microorganisms, and also found in marine invertebrates and algae. The greatest number of them is found in Plants belonging to the genus Taxus. Oxetanes are high-energy oxygen-containing non-aromatic heterocycles that are of great interest as new potential pharmacophores with a significant spectrum of biological activities. The biological activity of OCC that is produced by bacteria and Actinomycetes demonstrates antineoplastic, Antiviral (arbovirus), and Antifungal activity with confidence an angiogenesis stimulator, respiratory analeptic, and antiallergic activity dominate with confidence from 81 to 99%.

Keywords

Activities; Algae; Cyclobutane; Fungi; Invertebrates; Microorganisms; Oxetane; Plant.

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