2. Academic Validation
  3. Unmodified household coffee maker assisted extraction and purification of anticancer agents from Dillenia indica fruits

Unmodified household coffee maker assisted extraction and purification of anticancer agents from Dillenia indica fruits

  • Nat Prod Res. 2021 Mar;35(6):984-987. doi: 10.1080/14786419.2019.1608546.
Mohsin Ali Khan 1,  Tanveer Ahamad 2,  Mohammad Saquib 3,  Mohd Kamil Hussain 4,  Mohammad Faheem Khan 2 5
Affiliations

Affiliations

  • 1 Research Unit, Era's Lucknow Medical College & Hospital, Era University, Lucknow, UP, India.
  • 2 Department of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, UP, India.
  • 3 Department of Chemistry, University of Allahabad, Allahabad, UP, India.
  • 4 Department of Chemistry, Government Raza Post Graduate College, Rampur, UP, India.
  • 5 Department of Chemistry, Era University, Lucknow, UP, India.
PMID: 31134812 DOI: 10.1080/14786419.2019.1608546
Abstract

Bioassay targeted, 80% aqueous ethanol crude extract of the fruits of Dillenia indica Linn, using the unmodified household coffee maker, afforded five compounds, namely betulinic acid (1), rhamnazin (2), dillenetin (3), luteolin-7-O-β-D-glucoside (4) and hypolaetin-8-O-β-D-glucoside (5). The crude extract, fractions and purified compounds were tested against MDA MB-231, A549 and HeLa Cancer cell lines by MTT assay, using betulinic acid 1, as a positive control. Compound 3 showed the best activity against A549 (IC50 = 26.60 ± 2.5 µM) and HeLa Cancer cell lines (IC50 =19.35 ± 0.9 µM), whereas compound 5 was found to show the best activity against MDA MB-231 (IC50 = 34.62 ± 5.2µM) Cancer cell line. These highly potent Anticancer compounds obtained from the fruits of D. indica may be suitable for herbal drug development and formulations.

Keywords

Dillenia indica; anticancer agents; betulinic acid; household coffee maker.

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