2. Academic Validation
  3. Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI

Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI

  • Front Neurosci. 2019 Sep 13;13:980. doi: 10.3389/fnins.2019.00980.
Li Kuai 1 2,  Jianhua Peng 3 4,  Yong Jiang 3 5 6,  Zheng Zheng 1,  Xiyuan Zhou 1
Affiliations

Affiliations

  • 1 Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 2 Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • 3 Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • 4 Neurosurgery Clinical Medical Research Center of Sichuan Province, Luzhou, China.
  • 5 Academician Expert Workstation, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • 6 Laboratory of Neurological Diseases and Brain Functions, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
PMID: 31607842 DOI: 10.3389/fnins.2019.00980
Abstract

Vision loss after traumatic optic nerve injury (TONI) is considered irreversible because of the retrograde loss of retinal ganglion cells (RGCs), which undergo inflammation and Apoptosis. Previous studies have shown that COG1410, a mimic peptide derived from the apolipoprotein E (apoE) receptor binding region, shows neuroprotective activity in acute brain injury. However, the detailed role and mechanisms of COG1410 in RGC survival and vision restoration after TONI are poorly understood. The current study aimed to investigate the effects of COG1410 on inflammation and Apoptosis in a mouse model of TONI. The results showed that TONI-induced visual impairment was accompanied by optic nerve inflammation, Apoptosis, edema, and RGC Apoptosis. COG1410 significantly prevented the decrease in visual from ever occurring, attenuated inflammation and Apoptosis, and reduced optic nerve edema and RGC Apoptosis compared with vehicle treatment. These data identify protective roles of COG1410 in the inflammatory and apoptotic processes of TONI, as well as strategies for its treatment.

Keywords

COG1410; apoptosis; inflammation; magnetic resonance imaging; traumatic optic nerve injury.

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