1. Academic Validation
  2. Guidelines and definitions for research on epithelial-mesenchymal transition

Guidelines and definitions for research on epithelial-mesenchymal transition

  • Nat Rev Mol Cell Biol. 2020 Jun;21(6):341-352. doi: 10.1038/s41580-020-0237-9.
Jing Yang 1 Parker Antin 2 Geert Berx 3 Cédric Blanpain 4 Thomas Brabletz 5 Marianne Bronner 6 Kyra Campbell 7 Amparo Cano 8 Jordi Casanova 9 Gerhard Christofori 10 Shoukat Dedhar 11 Rik Derynck 12 Heide L Ford 13 Jonas Fuxe 14 Antonio García de Herreros 15 Gregory J Goodall 16 Anna-Katerina Hadjantonakis 17 Ruby Y J Huang 18 Chaya Kalcheim 19 Raghu Kalluri 20 Yibin Kang 21 Yeesim Khew-Goodall 22 Herbert Levine 23 Jinsong Liu 24 Gregory D Longmore 25 Sendurai A Mani 26 Joan Massagué 27 Roberto Mayor 28 David McClay 29 Keith E Mostov 30 Donald F Newgreen 31 M Angela Nieto 32 Alain Puisieux 33 34 Raymond Runyan 2 Pierre Savagner 35 Ben Stanger 36 Marc P Stemmler 5 Yoshiko Takahashi 37 Masatoshi Takeichi 38 Eric Theveneau 39 Jean Paul Thiery 40 Erik W Thompson 41 Robert A Weinberg 42 Elizabeth D Williams 43 Jianhua Xing 44 Binhua P Zhou 45 Guojun Sheng 46 EMT International Association (TEMTIA)
Affiliations

Affiliations

  • 1 Departments of Pharmacology and Pediatrics, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. jingyang@ucsd.edu.
  • 2 Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
  • 3 Molecular and Cellular Oncology Lab, Department of Biomedical Molecular Biology, Ghent University, Cancer Research Institute Ghent (CRIG), VIB Center for Inflammation Research, Ghent, Belgium.
  • 4 Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Bruxelles, Belgium.
  • 5 Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
  • 6 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • 7 Department of Biomedical Science and Bateson Centre, University of Sheffield, Sheffield, UK.
  • 8 Departamento de Bioquímica, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM), IdiPAZ & Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
  • 9 Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology/Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona, Spain.
  • 10 Department of Biomedicine, University of Basel, Basel, Switzerland.
  • 11 Department of Biochemistry and Molecular Biology, University of British Columbia and British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • 12 Departments of Cell and Tissue Biology, and Anatomy, University of California at San Francisco, San Francisco, CA, USA.
  • 13 Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • 14 Department of Laboratory Medicine (LABMED), Division of Pathology, Karolinska University Hospital and Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.
  • 15 Programa de Recerca en Càncer, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM) and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
  • 16 Centre for Cancer Biology, An alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.
  • 17 Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • 18 School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
  • 19 Department of Medical Neurobiology, Institute for medical Research Israel-Canada and the Safra Center for Neurosciences, Hebrew University of Jerusalem, Hadassah Medical School, Jerusalem, Israel.
  • 20 Department of Cancer Biology, Metastasis Research Center, MD Anderson Cancer Center, Houston, TX, USA.
  • 21 Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
  • 22 Centre for Cancer Biology, an Alliance of SA Pathology and the University of South Australia, Adelaide, SA, Australia.
  • 23 Department of Physics, Northeastern University, Boston, MA, USA.
  • 24 Department of Anatomic Pathology, The Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • 25 Department of Medicine (Oncology) and Department of Cell Biology and Physiology, ICCE Institute, Washington University, St. Louis, MO, USA.
  • 26 Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • 27 Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • 28 Department of Cell and Developmental Biology, University College London, London, UK.
  • 29 Department of Biology, Duke University, Durham, NC, USA.
  • 30 Departments of Anatomy and Biochemistry/Biophysics, University of California, San Francisco, School of Medicine, San Francisco, CA, USA.
  • 31 Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
  • 32 Instituto de Neurociencias (CSIC-UMH) Avda Ramon y Cajal s/n, Sant Joan d´Alacant, Spain.
  • 33 Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.
  • 34 Institut Curie, PSL Research University, Paris, France.
  • 35 INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, University Paris-Saclay, Villejuif, France.
  • 36 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • 37 Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan.
  • 38 RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
  • 39 Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.
  • 40 Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China.
  • 41 School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Woolloongabba, QLD, Australia.
  • 42 Whitehead Institute for Biomedical Research, Department of Biology, MIT Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • 43 Australian Prostate Cancer Research Centre-Queensland (APCRC-Q) and Queensland Bladder Cancer Initiative (QBCI), School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD, Australia.
  • 44 Department of Computational and Systems Biology and UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
  • 45 Department of Molecular and Cellular Biochemistry and UK Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, USA.
  • 46 International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan. sheng@kumamoto-u.ac.jp.
Abstract

Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting Cancer and Other Diseases depend on the adoption of a unified terminology to describe EMT.

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