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  2. Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

  • Nat Prod Bioprospect. 2021 Feb;11(1):51-62. doi: 10.1007/s13659-020-00262-0.
Hong-Jie Zhu  # 1 Te Xu  # 2 Yong-Ming Yan 2 Zheng-Chao Tu 3 4 Yong-Xian Cheng 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
  • 2 School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, 518060, People's Republic of China.
  • 3 International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China.
  • 4 Drug Discovery Pipeline & Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Guangzhou, 510530, People's Republic of China.
  • 5 School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, 518060, People's Republic of China. yxcheng@szu.edu.cn.
  • # Contributed equally.
Abstract

Ten neolignans or norlignans (1-10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human Cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation.

Keywords

Anticoagulant activity; Insect medicine; Lignans; Polyphaga plancyi; Renal protection.

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