2. Academic Validation
  3. Isolation and characterization of two new chroman-4-ones from the endophytic fungus Penicillium chrysogenum obtained from Eucommia ulmoides Oliver

Isolation and characterization of two new chroman-4-ones from the endophytic fungus Penicillium chrysogenum obtained from Eucommia ulmoides Oliver

  • Nat Prod Res. 2022 Jul;36(13):3297-3302. doi: 10.1080/14786419.2020.1855161.
Sheng-Yue Liu 1,  Li-Zhi Wang 1,  Yue-Fei Wang 1,  Lin Li 1,  Guo-Ying Han 1,  Bing-Yang Zhang 1,  Ying Guo 2,  Yong-Zhi He 1,  Shi-Ming Fang 1,  Han Zhang 1
Affiliations

Affiliations

  • 1 Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • 2 Department of Neurology, Tianjin Nankai Hospital, Tianjin, China.
PMID: 33930984 DOI: 10.1080/14786419.2020.1855161
Abstract

Two new chroman-4-ones penicichromanone A (1) and penicichromanone B (2), together with three known compounds conioxepinol C (3), emodin (4) and moniliphenone (5), were obtained from the endophytic fungus Penicillium chrysogenum, which was isolated from the bark of Eucommia ulmoides Oliver. The structures of 1 and 2 were elucidated by detailed analysis of HRESIMS, 1D/2D NMR and ECD spectra. All the compounds were evaluated for their anti-inflammatory activities using HEK293 cells, and compounds 1, 3, 4 and 5 exhibited significant inhibitory effects on TNF-α-stimulated NF-κB activation.

Keywords

Eucommia ulmoides Oliver; NF-κB; Penicillium chrysogenum; chroman-4-ones.

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