2. Academic Validation
  3. TIGIT-Fc Promotes Antitumor Immunity

TIGIT-Fc Promotes Antitumor Immunity

  • Cancer Immunol Res. 2021 Sep;9(9):1088-1097. doi: 10.1158/2326-6066.CIR-20-0986.
Xian Shen # 1,  Wenyan Fu # 2 3,  Yongpeng Wei # 4,  Junle Zhu 2 5,  Yue Yu 2 6,  Changhai Lei 2,  Jian Zhao 7 8,  Shi Hu 9
Affiliations

Affiliations

  • 1 Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, P.R. China.
  • 2 Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, P.R. China.
  • 3 Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
  • 4 The Fifth Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, P.R. China.
  • 5 Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, P.R. China.
  • 6 Department of Thyroid and Breast Surgery, First Affiliated Hospital, Second Military Medical University, Shanghai, P.R. China.
  • 7 Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, P.R. China.
  • 8 KOCHKOR Biotech, Inc., Shanghai, P.R. China.
  • 9 Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, P.R. China. hus@smmu.edu.cn.
  • # Contributed equally.
PMID: 34244300 DOI: 10.1158/2326-6066.CIR-20-0986
Abstract

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a checkpoint receptor that mediates both T-cell and natural killer (NK)-cell exhaustion in tumors. An Fc-TIGIT fusion protein was shown to induce an immune-tolerance effect in a previous report, but the relevance of the TIGIT-Fc protein to tumor immunity is unknown. Here, we found that TIGIT-Fc promotes, rather than suppresses, tumor immunity. TIGIT-Fc treatment promoted the effector function of CD8+ T and NK cells in several tumor-bearing mouse models. TIGIT-Fc treatment resulted in potent T cell- and NK cell-mediated tumor reactivity, sustained memory-induced immunity in tumor rechallenge models, enhanced therapeutic effects via an antibody against PD-L1, and induction of Th1 development in CD4+ T cells. TIGIT-Fc showed a potent antibody-dependent cell-mediated cytotoxicity effect but had no intrinsic effect on tumor cell development. Our findings elucidate the role of TIGIT-Fc in tumor immune reprogramming, suggesting that TIGIT-Fc treatment alone or in combination with Other checkpoint receptor blockers is a promising Anticancer therapeutic strategy.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-P9986
    99.04%, TIGIT抑制剂
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z