2. Academic Validation
  3. Three Previously Undescribed Chlorophenyl Glycosides from the Bulbs of Lilium regale

Three Previously Undescribed Chlorophenyl Glycosides from the Bulbs of Lilium regale

  • Chem Biodivers. 2021 Oct;18(10):e2100403. doi: 10.1002/cbdv.202100403.
Jie Yan 1 2 3,  Wenxiu Guo 2,  Lanyu Zhou 2,  Dale Guo 1 2,  Jin Pei 1 2,  Yun Deng 1 2,  Haoyuan Zheng 3,  Ding Liu 3,  Xiaofang Xie 1 2,  Cheng Peng 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
  • 2 College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
  • 3 Chengdu Push Bio-technology Co., Ltd., Chengdu, 610000, P. R. China.
PMID: 34370372 DOI: 10.1002/cbdv.202100403
Abstract

Three previously undescribed chlorophenyl glycosides, (2,4,6-trichloro-3-hydroxy-5-methoxyphenyl)methyl β-D-glucopyranoside (1), (2,4-dichloro-3,5-dimethoxyphenyl)methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside (2) and 4-chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside (3) were obtained from Lilium regale. The absolute configurations of these new finds were elucidated by comprehensive analyses of spectroscopic data combined with acid hydrolysis derivatization. (2,4-dichloro-3,5-dimethoxyphenyl)methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside (2) can inhibit the proliferation of lung carcinoma A549 cells with an IC50 value of 29 μΜ.

Keywords

Lilium regale; anti-proliferative activity; chlorophenyl glycosides; structural elucidation.

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