2. Academic Validation
  3. HDAC11 Regulates the Proliferation of Bovine Muscle Stem Cells through the Notch Signaling Pathway and Inhibits Muscle Regeneration

HDAC11 Regulates the Proliferation of Bovine Muscle Stem Cells through the Notch Signaling Pathway and Inhibits Muscle Regeneration

  • J Agric Food Chem. 2022 Jul 27;70(29):9166-9178. doi: 10.1021/acs.jafc.2c03384.
Ruimen Zhang 1,  Yu Pan 1,  Wanyou Feng 1,  Yimin Zhao 1,  Yanyan Yang 1,  Leyi Wang 1,  Yongwang Zhang 1,  Juanru Cheng 1,  Qinyang Jiang 2,  Zihua Zheng 3,  Mingsheng Jiang 2,  Sufang Yang 4,  Yanfei Deng 1,  Deshun Shi 1,  Yingming Wei 2
Affiliations

Affiliations

  • 1 State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning, Guangxi 530004, People's Republic of China.
  • 2 College of Animal Science and Technology, Guangxi University, Nanning, Guangxi 530004, People's Republic of China.
  • 3 State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Institute for Agricultural and Animal Husbandry Industry Development, Guangxi University, Nanning, Guangxi 530004, People's Republic of China.
  • 4 State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, International Zhuang Medical Hospital Affiliated to Guangxi University Chinese Medicine, Nanning, Guangxi 530000, People's Republic of China.
PMID: 35837734 DOI: 10.1021/acs.jafc.2c03384
Abstract

Myogenesis is an essential process that can affect the yield and quality of beef. Transcriptional studies have shown that histone deacetylase 11 (HDAC11) was differentially expressed in muscle tissues of 6 and 18 month old Longlin cattle, but its role in the regulation of myogenesis remains unclear. This study aimed to determine the role of HDAC11 in the proliferation and differentiation of bovine muscle stem cells (MuSCs). HDAC11 promoted MuSC proliferation by activating Notch signaling and inhibited myoblast differentiation by reducing MyoD1 transcription. In addition, overexpression of HDAC11 inhibited the repair regeneration process of muscle in mice. HDAC11 was found to be a novel key target for the control of myogenesis, and this is a theoretical basis for the development of HDAC11-specific modulators as a new strategy to regulate myogenesis.

Keywords

HDAC11; Longlin cattle; Notch signaling pathway; cell proliferation; longissimus dorsi; muscle stem cells.

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