2. Academic Validation
  3. IL-6 drives T cell death to participate in lymphopenia in COVID-19

IL-6 drives T cell death to participate in lymphopenia in COVID-19

  • Int Immunopharmacol. 2022 Oct:111:109132. doi: 10.1016/j.intimp.2022.109132.
Xiaoqi Zhou 1,  Guangming Ye 2,  Yibing Lv 3,  Yanyan Guo 3,  Xingfei Pan 4,  Yirong Li 2,  Guanxin Shen 3,  Yong He 5,  Ping Lei 6
Affiliations

Affiliations

  • 1 Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Nuclear Medicine and PET Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • 2 Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • 3 Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 4 Department of Infectious Diseases, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • 5 Department of Nuclear Medicine and PET Center, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: heyong@znhospital.cn.
  • 6 Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: adaleip@hust.edu.cn.
PMID: 35964413 DOI: 10.1016/j.intimp.2022.109132
Abstract

Lymphopenia is a common observation in patients with COVID-19. To explore the cause of T cell lymphopenia in the disease, laboratory results of 64 hospitalized COVID-19 patients were retrospectively analyzed and six patients were randomly selected to trace their changes of T lymphocytes and plasma concentration of IL-6 for the course of disease. Results confirmed that the T-cell lymphopenia, especially CD4+ T cell reduction in COVID-19 patients, was a reliable indicator of severity and hospitalization in infected patients. And CD4+ T cell count below 200 cells/μL predicts critical illness in COVID-19 patients. In vitro assay supported that exposure to key contributors (IL-1β, IL-6, TNF-α and IFN-γ) of COVID-19 cytokine storm caused substantial death of activated T cells. Among these contributors, IL-6 level was found to probably reversely correlate with T cell counts in patients. And IL-6 alone was potent to induce T cell reduction by gasderminE-mediated Pyroptosis, inferring IL-6 took a part in affecting the function and status of T cells in COVID-19 patients. Intervention of IL-6 mediated T cell pryprotosis may effectively delay disease progression, maintain normal immune status at an early stage of Infection.

Keywords

COVID-19; ICU care; IL-6; Lymphopenia; SARS-CoV-2.

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