2. Academic Validation
  3. Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes

Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes

  • Immunity. 2023 Jan 10;56(1):207-223.e8. doi: 10.1016/j.immuni.2022.12.007.
Yun Hsuan Lin 1,  Han G Duong 1,  Abigail E Limary 1,  Eleanor S Kim 1,  Paul Hsu 1,  Shefali A Patel 1,  William H Wong 1,  Cynthia S Indralingam 1,  Yi Chia Liu 1,  Priscilla Yao 1,  Natalie R Chiang 1,  Sara A Vandenburgh 1,  Taylor R Anderson 1,  Jocelyn G Olvera 1,  Amir Ferry 2,  Kennidy K Takehara 2,  Wenhao Jin 3,  Matthew S Tsai 1,  Gene W Yeo 4,  Ananda W Goldrath 2,  John T Chang 5
Affiliations

Affiliations

  • 1 Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • 2 Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
  • 3 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • 4 Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • 5 Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA; Department of Medicine, Jennifer Moreno Department of Veteran Affairs Medical Center, San Diego, CA 92161, USA. Electronic address: changj@ucsd.edu.
PMID: 36580919 DOI: 10.1016/j.immuni.2022.12.007
Abstract

Tissue-resident memory CD8+ T (TRM) cells are a subset of memory T cells that play a critical role in limiting early pathogen spread and controlling Infection. TRM cells exhibit differences across tissues, but their potential heterogeneity among distinct anatomic compartments within the small intestine and colon has not been well recognized. Here, by analyzing TRM cells from the lamina propria and epithelial compartments of the small intestine and colon, we showed that intestinal TRM cells exhibited distinctive patterns of cytokine and granzyme expression along with substantial transcriptional, epigenetic, and functional heterogeneity. The T-box transcription factor Eomes, which represses TRM cell formation in some tissues, exhibited unexpected context-specific regulatory roles in supporting the maintenance of established TRM cells in the small intestine, but not in the colon. Taken together, these data provide previously unappreciated insights into the heterogeneity and differential requirements for the formation vs. maintenance of intestinal TRM cells.

Keywords

Eomes; colon; single-cell ATAC-sequencing; single-cell RNA-sequencing; small intestine; tissue-resident memory CD8(+) T cells.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z