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  3. Guaiazulene and related compounds: A review of current perspective on biomedical applications

Guaiazulene and related compounds: A review of current perspective on biomedical applications

  • Life Sci. 2023 Mar 1:316:121389. doi: 10.1016/j.lfs.2023.121389.
Wasim Akram 1,  Priti Tagde 2,  Sakeel Ahmed 3,  Swamita Arora 4,  Talha Bin Emran 5,  Ahmad O Babalghith 6,  Sherouk Hussein Sweilam 7,  Jesus Simal-Gandara 8
Affiliations

Affiliations

  • 1 Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
  • 2 Amity Institute of Pharmacy, Amity University Campus, Sector 125, Noida 201313, UP, India; PRISAL Foundation (Pharmaceutical Royal International Society), India. Electronic address: tagde_priti@rediffmail.com.
  • 3 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad, India.
  • 4 Amity Institute of Pharmacy, Amity University Campus, Sector 125, Noida 201313, UP, India.
  • 5 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
  • 6 Medical Genetics Department, College of Medicine, Umm Alqura University, Makkah, Saudi Arabia.
  • 7 Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Egyptian Russian University, Cairo-Suez Road, Badr City 11829, Egypt.
  • 8 Universidade de Vigo, Nutrition and Bromatology Group, Analytical Chemistry and Food Science Department, Faculty of Science, E32004 Ourense, Spain. Electronic address: jsimal@uvigo.es.
PMID: 36646376 DOI: 10.1016/j.lfs.2023.121389
Abstract

Background: Thousands of people worldwide pass away yearly due to neurological disorders, cardiovascular illnesses, Cancer, metabolic disorders, and microbial infections. Additionally, a sizable population has also been impacted by hepatotoxicity, ulcers, gastroesophageal reflux disease, and breast fissure. These ailments are likewise steadily increasing along with the increase in life expectancy. Finding innovative therapies to cure and consequently lessen the impact of these ailments is, therefore, a global concern.

Methods and materials: All provided literature on Guaiazulene (GA) and its related compounds were searched using various electronic databases such as PubMed, Google Scholar, Web of Science, Elsevier, Springer, ACS, CNKI, and books via the keywords Guaiazulene, Matricaria chamomilla, GA-related compounds, and Guaiazulene analogous.

Results: The FDA has approved the bicyclic sesquiterpene GA, commonly referred to as azulon or 1,4-dimethyl-7-isopropylazulene, as a component in cosmetic colorants. The pleiotropic health advantages of GA and related substances, especially their antioxidant and anti-inflammatory effects, attracted a lot of research. Numerous studies have found that GA can help to manage various conditions, including Bacterial infections, tumors, immunomodulation, expectorants, diuretics, diaphoresis, ulcers, dermatitis, proliferation, and gastritis. These conditions all involve lipid peroxidation and inflammatory response. In this review, we have covered the biomedical applications of GA. Moreover, we also emphasize the therapeutic potential of guaiazulene derivatives in pre-clinical and clinical settings, along with their underlying mechanism(s).

Conclusion: GA and its related compounds exhibit therapeutic potential in several diseases. Still, it is necessary to investigate their potential in animal models for various Other ailments and establish their safety profile. They might be a good candidate to advance to clinical trials.

Keywords

Guaiazulene; Guaiazulene SAR; Guaiazulene analogous; Herbal drugs; Pharmacological actions.

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