2. Academic Validation
  3. Sinococuline, a bioactive compound of Cocculus hirsutus has potent anti-dengue activity

Sinococuline, a bioactive compound of Cocculus hirsutus has potent anti-dengue activity

  • Sci Rep. 2023 Jan 19;13(1):1026. doi: 10.1038/s41598-023-27927-3.
Rahul Shukla 1 2,  Richa Ahuja 1 3,  Hemalatha Beesetti 3 4,  Amit Garg 1,  Charu Aggarwal 1,  Shivam Chaturvedi 1,  Kaushal Nayyar 3,  Upasana Arora 3,  Altaf A Lal 3,  Navin Khanna 5 6
Affiliations

Affiliations

  • 1 Translational Health, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
  • 2 Division of Virus Research and Therapeutics, CSIR-Central Drug Research Institute, Lucknow, India.
  • 3 Sun Pharmaceutical Industries Limited, Gurugram, India.
  • 4 Virology Division, Foundation for Neglected Disease Research, 20A, KIADB Industrial Area Veerapura, Doddaballapur, Bengaluru, Karnataka, 561203, India.
  • 5 Translational Health, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India. navinkhanna5@gmail.com.
  • 6 Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India. navinkhanna5@gmail.com.
PMID: 36658277 DOI: 10.1038/s41598-023-27927-3
Abstract

Dengue virus (DENV) Infection has increased worldwide, with over 400 million infections annually, and has become a serious public health concern. Several drug candidates, new and repurposed, have failed to meet the primary efficacy endpoints. We have recently shown that Aqueous Extract of the stem of Cocculus hirsutus (AQCH) was effective in vitro and in vivo against DENV and was safe in humans. We now report that an active ingredient of AQCH, Sinococuline, protects against the antibody-mediated secondary-DENV Infection in the AG129 mouse model. DENV Infection markers were assessed, viz. serum viremia and vital organs pathologies-viral load, proinflammatory cytokines and intestinal vascular leakage. The treatment with Sinococuline at 2.0 mg/kg/day; BID (twice a day), was the most effective in protecting the severely DENV-infected AG129 mice. Also, this dose effectively reduced serum viremia and tissue-viral load and inhibited the elevated expression levels of proinflammatory cytokines (TNF-α and IL-6) in several vital organs. Based on these findings, it could be explored further for pre-clinical and clinical developments for the treatment of dengue.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z