2. Academic Validation
  3. Biopolymer-Based Nanosystems for siRNA Drug Delivery to Solid Tumors including Breast Cancer

Biopolymer-Based Nanosystems for siRNA Drug Delivery to Solid Tumors including Breast Cancer

  • Pharmaceutics. 2023 Jan 1;15(1):153. doi: 10.3390/pharmaceutics15010153.
Md Abdus Subhan 1,  Vladimir P Torchilin 2 3
Affiliations

Affiliations

  • 1 Department of Chemistry, ShahJalal University of Science and Technology, Sylhet 3114, Bangladesh.
  • 2 CPBN, Department of Pharmaceutical Sciences, North Eastern University, Boston, MA 02115, USA.
  • 3 Department of Chemical Engineering, North Eastern University, Boston, MA 02115, USA.
PMID: 36678782 DOI: 10.3390/pharmaceutics15010153
Abstract

Nanobiopolymers such as chitosan, gelatin, hyaluronic acid, polyglutamic acid, lipids, peptides, exosomes, etc., delivery systems have prospects to help overwhelmed physiological difficulties allied with the delivery of siRNA drugs to solid tumors, including breast Cancer cells. Nanobiopolymers have favorable stimuli-responsive properties and therefore can be utilized to improve siRNA delivery platforms to undruggable MDR metastatic Cancer cells. These biopolymeric siRNA drugs can shield drugs from pH degradation, extracellular trafficking, and nontargeted binding sites and are consequently suitable for drug internalization in a controlled-release fashion. In this review, the utilization of numerous biopolymeric compounds such as siRNA drug delivery systems for MDR solid tumors, including breast cancers, will be discussed.

Keywords

biopolymer; breast cancer; drug delivery; siRNA therapy; solid tumors.

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