2. Academic Validation
  3. Procyanidin alleviates ferroptosis and inflammation of LPS-induced RAW264.7 cell via the Nrf2/HO-1 pathway

Procyanidin alleviates ferroptosis and inflammation of LPS-induced RAW264.7 cell via the Nrf2/HO-1 pathway

  • Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov 27. doi: 10.1007/s00210-023-02854-2.
Jiayan Zeng # 1,  Yanmin Weng # 1,  Tianli Lai # 1,  Lan Chen 1,  Ying Li 1,  Qiqi Huang 1,  Saiyi Zhong 2,  Shibiao Wan 3,  Lianxiang Luo 4 5
Affiliations

Affiliations

  • 1 The First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
  • 2 Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, 524088, China.
  • 3 Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA. swan@unmc.edu.
  • 4 The Marine Biomedical Research Institute, Guangdong Medical University, No. 2 Wenming East Road, Xiashan District, Zhanjiang, 524023, Guangdong, China. luolianxiang321@gdmu.edu.cn.
  • 5 The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong, 524023, China. luolianxiang321@gdmu.edu.cn.
  • # Contributed equally.
PMID: 38010399 DOI: 10.1007/s00210-023-02854-2
Abstract

Inflammation is a common occurrence in many medical conditions and is a natural defense mechanism of the human body. Ferroptosis, an iron-dependent form of cell death related to lipid peroxide build-up, has been found to be involved in inflammation. The anti-inflammatory effects of procyanidin, however, are not yet fully understood. Through network pharmacology and bioinformatics analysis, it was suggested that procyanidin could modulate Ferroptosis and cause anti-inflammatory effects on RAW264.7 cells. This was further evidenced through molecular docking, molecular dynamics, and in vitro experiments. The results indicated that procyanidin could diminish inflammation in LPS-induced RAW264.7 cells by regulating Ferroptosis via the Nrf2/HO-1/Keap-1 pathway. In conclusion, procyanidin supplementation might be an effective way to reduce inflammation by decreasing the release of inflammatory cytokines and suppressing Ferroptosis.

Keywords

Ferroptosis; Inflammation; Nrf2/HO-1/Keap-1 pathway; Procyanidin.

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