1. Academic Validation
  2. Tailored gelatin methacryloyl-based hydrogel with near-infrared responsive delivery of Qiai essential oils boosting reactive oxygen species scavenging, antimicrobial, and anti-inflammatory activities for diabetic wound healing

Tailored gelatin methacryloyl-based hydrogel with near-infrared responsive delivery of Qiai essential oils boosting reactive oxygen species scavenging, antimicrobial, and anti-inflammatory activities for diabetic wound healing

  • Int J Biol Macromol. 2024 Feb 22;263(Pt 2):130386. doi: 10.1016/j.ijbiomac.2024.130386.
Na Meng 1 Chuchao Zhou 2 Zhiwei Sun 2 Xiangru Chen 2 Shaotang Xiong 3 Mengjuan Tao 4 Yueyue Qin 1 Keqiang Hu 2 Liya Ma 5 Di Tian 6 Fen Zhu 7 Yanqing Yang 8
Affiliations

Affiliations

  • 1 Department of Cardiovascular Medicine, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan 430060, China.
  • 2 Department of Plastic Surgery, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan 430060, China.
  • 3 The Second People's Hospital of China Three Gorges University, The Second People's Hospital of Yichang, Hubei, China.
  • 4 Department of Clinical Laboratory, Wuhan Center for Clinical Laboratory, Wuhan, Hubei, China.
  • 5 The Centre of Analysis and Measurement of Wuhan University, Wuhan University, Wuhan 430072, China.
  • 6 Hubei Key Laboratory of Biomass Fibers and Eco-dyeing & Finishing, Department of Chemistry and Chemical Engineering, Wuhan Textile University, Wuhan 430073, China.
  • 7 Department of Cardiovascular Medicine, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan 430060, China. Electronic address: 1315007136@qq.com.
  • 8 Department of Plastic Surgery, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan 430060, China. Electronic address: yangyq0106@163.com.
Abstract

The management of diabetic wounds poses a substantial economic and medical burden for diabetic patients. Oxidative stress and persistent Bacterial infections are considered to be the primary factors. Qiai essential oil (QEO) exhibits various pharmacological characteristics, including inflammatory-reducing, Antibacterial, and antioxidant properties. Nevertheless, the hydrophobic nature and propensity for explosive release of this substance present constraints on its potential for future applications. Here, we developed a stimulus-responsive hydrogel to overcome the multiple limitations of QEO-based wound dressings. The QEO was encapsulated within graphene oxide (GO) through repeated extrusion using an extruder. Subsequently, QEO@GO nanoparticles were incorporated into a Gelatin-methacryloyl (GelMA) hydrogel. The QEO@GO-GelMA hydrogel demonstrated controlled release ablation, photothermal Antibacterial effects, and contact ablation against two representative Bacterial strains. It effectively reduced Reactive Oxygen Species (ROS) generation, promoted angiogenesis, and decreased levels of the pro-inflammatory cytokine interleukin-6 (IL-6), thereby accelerating the healing process of diabetic wounds. In addition, in vitro and in vivo tests provided further evidence of the favorable biocompatibility of this multifunctional hydrogel dressing. Overall, the QEO@GO-GelMA hydrogel provides numerous benefits, encompassing antimicrobial properties, ROS-scavenging abilities, anti-inflammatory effects, and the capacity to expedite diabetic wound healing. These attributes make it an optimal choice for diabetic wound management.

Keywords

Diabetic wound healing; Graphene oxide; Qiai essential oil; Stimulus-responsive hydrogel.

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