Tumor-adipose assembloids reveal cell-fate-transition-triggered multistage collective invasions

Affiliations

• 1 The Key Laboratory of Molecular Biophysics of MOE and Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology - The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.
• 2 Department of Gastroenterology, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Institute of Liver and Gastrointestinal Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.
• 3 Department of Laboratory Medicine, Center for Single-Cell Omics and Tumor Liquid Biopsy, Zhongnan Hospital of Wuhan University, Wuhan 430074, China.
• 4 School of Systems Science and Institute of Nonequilibrium Systems, Beijing Normal University, Beijing 100875, China.
• 5 Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
• 6 School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen 518100, China.
• 7 The Key Laboratory of Molecular Biophysics of MOE and Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology - The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address: bfliu@mail.hust.edu.cn.
• 8 The Key Laboratory of Molecular Biophysics of MOE and Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology - The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address: yiweili@hust.edu.cn.