2. Academic Validation
  3. Monitoring of Cerebral ROS and Alleviating Depressive-like Phenotype with a Curcumin-Derived Theranostic Probe

Monitoring of Cerebral ROS and Alleviating Depressive-like Phenotype with a Curcumin-Derived Theranostic Probe

  • ACS Chem Neurosci. 2025 Oct 1;16(19):3745-3757. doi: 10.1021/acschemneuro.5c00355.
Liqiang Jin 1,  Yongjian Jiang 2,  Ruina Luo 2,  Xue Tian 2,  Sijin Jiang 2,  Wenjian Zhang 2,  Lu Gan 2,  Jian Yang 3,  Zhaojing Zhu 1,  Chao Yu 4,  Biyue Zhu 2
Affiliations

Affiliations

  • 1 Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P.R. China.
  • 2 Department of Pharmacy, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing 401122, P. R. China.
  • 3 School of Medicine, Shanghai University, Shanghai 200444, P.R. China.
  • 4 Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. China.
PMID: 40952025 DOI: 10.1021/acschemneuro.5c00355
Abstract

Reactive Oxygen Species (ROS) play a critical role in the pathogenesis of major depressive disorder (MDD), a global public health challenge with limited effective treatments. However, monitoring and regulating cerebral ROS in living systems remain challenging, limiting both mechanistic studies and treatment strategies. Here, we present CRANAD-61 (Cr-61), a curcumin-derived fluorescent probe, as a multifunctional theranostic agent for the lipopolysaccharide (LPS)-induced depression mouse model. Cr-61 exhibits a ratiometric fluorescence shift (red to green) upon reaction with ROS, enabling detection of ROS levels in the brain. Beyond its detection capabilities, Cr-61 actively scavenges excess ROS, alleviating oxidative stress through suppressing neuroinflammation and improving depressive-like phenotypes. The dual functionality of Cr-61 for ROS detection and therapeutic intervention opens new avenues for advancing the understanding of ROS dynamics as well as providing a novel therapeutic strategy for depression and Other ROS-associated diseases.

Keywords

CRANAD-61; ROS; depression; fluorescence probe; neuronal inflammation; small-molecule probe; theranostic probe.

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