Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling

Affiliations

• 1 Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
• 2 Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215021, China.
• 3 Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
• 4 Lab Center, Medical College of Soochow University, Suzhou 215123, China.
• 5 International Collaborative Centre on Big Science Plan for Purinergic Signaling, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
• 6 Department of Physiology and Neurobiology and Centre for Ion Channelopathy, Suzhou Medical College of Soochow University, Suzhou 215123, China.
• 7 Monash Suzhou Research Institute, Monash University, Suzhou Industrial Park, Suzhou 215000, China.
• 8 Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421 Homburg, Germany.
• 9 Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421 Homburg, Germany.