2. Academic Validation
  3. Grape Seed Proanthocyanins Extract Ameliorates the Neurotoxicity Induced by Fluoride Through mTOR/p70s6k Signaling Pathway in Vivo and in Vitro

Grape Seed Proanthocyanins Extract Ameliorates the Neurotoxicity Induced by Fluoride Through mTOR/p70s6k Signaling Pathway in Vivo and in Vitro

  • Cell Biochem Biophys. 2025 Sep 27. doi: 10.1007/s12013-025-01916-x.
Wenxin Zhao 1 2,  Zelin Gong 1 2,  Benjie Wang 1 2,  Zhiyu Wu 1 2,  Yiyuan Guo 1 2,  Shurong Wang 1 2,  Hao Zhai 1 2,  Xiaomei Zheng 1 2,  Lu Yang 3 4
Affiliations

Affiliations

  • 1 Department of Preventive Medicine, School of Medicine, Shihezi University, North 2th Road, Shihezi, 832000, Xinjiang, People's Republic of China.
  • 2 Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China.
  • 3 Department of Preventive Medicine, School of Medicine, Shihezi University, North 2th Road, Shihezi, 832000, Xinjiang, People's Republic of China. yanglu@shzu.edu.cn.
  • 4 Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, People's Republic of China. yanglu@shzu.edu.cn.
PMID: 41014453 DOI: 10.1007/s12013-025-01916-x
Keywords

Autophagy; Grape seed proanthocyanidin extract (GSPE); Neurotoxicity; Sodium fluoride; mTOR/p70s6k.

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