2. Academic Validation
  3. Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa

Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa

  • Antimicrob Agents Chemother. 2025 Oct 10:e0085725. doi: 10.1128/aac.00857-25.
Kaan Kocer 1 2,  Truong Nhat My 3 4,  Bui Tien Sy 3 4,  Lisa Göpel 1,  Thirumalaisamy P Velavan 3 5 6 7,  Le Huu Song 3 4 6,  Silke Peter 7 8,  Sébastien Boutin 1 2 9,  Adesola Olalekan 10,  Dennis Nurjadi 1 2 3
Affiliations

Affiliations

  • 1 Institute of Medical Microbiology, University of Lübeck and University Hospital Schleswig-Holstein Campus Lübeck, Lübeck, Germany.
  • 2 German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Lübeck, Germany.
  • 3 Vietnamese-German Centre for Medical Research (VG-CARE), Hanoi, Vietnam.
  • 4 108 Military Central Hospital, Hanoi, Vietnam.
  • 5 Faculty of Medicine, Duy Tan University, Da Nang, Vietnam.
  • 6 Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany.
  • 7 German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany.
  • 8 Institute of Medical Microbiology and Hygiene, Universitätsklinikum Tübingen, Tübingen, Germany.
  • 9 Airway Research Center North (ARCN), German Center for Lung Research (DZL), Lübeck, Germany.
  • 10 Department of Medical Laboratory Science, College of Medicine, University of Lagos, Lagos, Nigeria.
PMID: 41071171 DOI: 10.1128/aac.00857-25
Abstract

We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, blaNDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of blaNDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa.

Keywords

NDM; Pseudomonas aeruginosa; cefiderocol; taniborbactam; xeruborbactam.

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