2. Academic Validation
  3. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains

Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains

  • Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. doi: 10.1128/AAC.42.11.3035.
D Deidda 1,  G Lampis,  R Fioravanti,  M Biava,  G C Porretta,  S Zanetti,  R Pompei
Affiliations

Affiliation

  • 1 Dipartimento di Scienze Mediche, Cattedra di Microbiologia, Università di Cagliari, Cagliari, Italy.
PMID: 9797251 DOI: 10.1128/AAC.42.11.3035
Abstract

The pyrrole derivative BM212 [1, 5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)methyl-pyrrole] was shown to possess strong inhibitory activity against both Mycobacterium tuberculosis and some nontuberculosis mycobacteria. BM212 was inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-100725
    99.51%, MmpL3抑制剂
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