1. 重组蛋白
  2. Receptor Proteins
  3. Pattern Recognition Receptors
  4. RIG-I-like Receptor

RIG-I-like Receptor  (RIG-I 样受体)

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are a family of cytosolic pattern recognition receptors (PRRs) that recognize viral RNA and result in immunological response. RLRs include RIG-I (retinoic acid-inducible gene I), MDA5 (melanoma differentiation associated factor 5), and LGP2 (laboratory of genetics and physiology 2). They share a number of structural similarities including their organization into three distinct domains: 1) An N-terminal region consisting of tandem caspase activation and recruitment domains (CARD); 2) A central DExD/H box RNA helicase domain with the capacity to hydrolyze ATP and to bind RNA; 3) A repressor domain (RD) embedded within the carboxy-terminal domain (CTD). LGP2 lacks the CARDs and is widely thought to function as a regulator of RIG-I and MDA5. Upon RNA binding and oligomerization, RLRs interact with mitochondrial antiviral-signalling protein (MAVS) via CARD–CARD interactions. Activated MAVS then activates TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε), which phosphorylates IRF3 and IRF7; these, together with nuclear factor-κB (NF-κB), then induce transcription of the genes encoding type I interferons and other antiviral or immunoregulatory genes.

目录号 产品名 / 同用名 种属 表达系统
  • HY-P72170
    DDX58 Protein, Human (His)

    Antiviral innate immune response receptor RIG-I; DEAD box protein 58; RLR-1; RIG-I

    Human E. coli
    DDX58 蛋白是一种先天免疫受体,可检测细胞质病毒核酸并启动信号级联以产生 I 型干扰素。它与病毒 RNA 形成核糖核蛋白复合物并促进同源寡聚化。DDX58 Protein, Human (His) 是重组的 DDX58 蛋白,由 E. coli 表达,带有 N-6*His 标签。DDX58 Protein, Human (His) 全长 430 个氨基酸,分子量约为 ~53.3 kDa。
目录号 产品名 作用方式 纯度