1. Screening Libraries
  2. Fragment Library

片段化合物库 - Fragment Library

Cat. No.: HY-L032
Library Contents: XLSX PDF SDF

基于片段的药物开发(FBDD)非常适合先导化合物及功能探针的发现,片段化合物可以覆盖广阔的化学空间,也更易于后期进行结构优化。以片段化合物为基础的药物开发在制药行业已经相当成熟,已经有多种药物进入临床试验,其中vemurafenib和venetoclax两种药物已经获得批准上市。FBDD在学术界也同样具有很强的吸引力,尤其FBDD可以应对一些新颖,较难成药的靶点,这些靶点通常在现有的高通量筛选化合物库中没有有效的可与之匹配的化合物。

MCE 可以提供 14821 种片段化合物,这些化合物均符合“类药3原则(RO3)”,即分子量≤300 Da,氢供体(H-donors)≤3,氢受体(H-acceptors)≤3,cLogP ≤3。MCE片段化合物库是先导化合物的重要来源。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 片段化合物库

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
50 μL/well Solution (10 mM) Get quote In-stock
100 μL/well Solution (10 mM) Get quote In-stock
2 × 100 μL/well Solution (10 mM) Get quote In-stock

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sales@MedChemExpress.cn

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Description
& Advantages

•   A unique collection of 14821 fragment compounds for traditional lead identification via high-throughput screening (HTS).

•   The compounds follow the Rule of Three.

•   A useful tool for the fragment-based approach to drug discovery (FBDD).

•   More detailed compound information with structure, Molecular Weight, cLogP, H-donor and H-acceptor number.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Parameter Range Average Value
Molecular Weight ≤300 180.48
cLogP ≤3.0 1.6241
H-donors ≤3.0 2.03
H-acceptors ≤3.0 0.77
Product Details
Formulation:
A collection of 14821 fragment compounds supplied as pre-dissolved Solutions or Solid
Solution: 14821 compounds supplied in 10 mM solution.
Container:
96- or 384-well Plate with Peelable Foil Seal
Storage:
-80°C
Shipping:
Blue ice
Documentation

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    产品名称:
    Fragment Library
    目录号:
    HY-L032
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack