1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. SLN124

SLN124 

目录号: HY-132605
产品使用指南

SLN124 是一种靶向跨膜丝氨酸蛋白酶 6 (Tmprss6) 的 GalNac-siRNA。SLN124 由与 TMPRSS6-siRNA 结合的三聚体 GalNAc 配体组成。SLN124 具有作为 siRNA 剂恢复铁调素表达和使 β-地贫中铁稳态正常化的潜力。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SLN124 Chemical Structure

SLN124 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 哈根达斯、星巴克、KFC、百果园 等专属礼券

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SLN124 is a GalNac-siRNA targeting transmembrane serine protease 6 (Tmprss6). SLN124 is composed of a trimeric GalNAc ligand conjugated to TMPRSS6‐siRNA. SLN124 has the potential for an siRNA to restore hepcidin expression and normalise iron homeostasis in β‐thalassaemia[1].

体外研究
(In Vitro)

SLN124 comprises a double‐stranded 19mer RNA oligonucleotide with 2′‐O‐methyl,2′‐fluoro‐2′‐deoxy modifications and phosphorothioate bonds targeting TMPRSS6, which is linked to a tri‐antennary GalNAc unit at the 5′ end of the sense strand[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SLN124 (s.c.; 3 mg/kg; two dose on days 1 and 14), alone or in combination with the oral iron chelator deferiprone (DFP), not only suppresses Tmprss6 expression, but also normalises serum hepcidin levels, significantly improves erythropoiesis and reduced splenomegaly in 6‐month‐old female Hbbth3/+ mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
SLN124
目录号:
HY-132605
需求量: