1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. 5 alpha Reductase

5 alpha Reductase (5α-还原酶)

Steroid 5-α reductase (5AR) is a membrane-bound protein that is responsible for reducing steroids such as testosterone, progesterone, and androstenedione to 5-α reduced metabolites such as 5-α dihydrotestosterone (DHT), 5-α dihydroprogesterone and androstanedione, respectively. There are three isoforms of 5AR in humans: SRD5A1, SRD5A2, and SRD5A3. SRD5A1 and SRD5A2 have functionality for 5-α reduction of steroids in humans. DHT is a more potent androgen than testosterone and has a function in androgen receptor activation.

The inactivating mutations in 5αR2 lead to disorders of sexual development. The regulation of 5AR is important for the treatment of benign prostate hyperplasia (BPH) and prostate cancer (PC), and 5AR inhibitors are widely used for the treatment of androgen-dependent benign or malignant prostatic diseases.

5 alpha Reductase 相关产品 (10):

目录号 产品名 作用方式 纯度
  • HY-13613
    Dutasteride Inhibitor 99.75%
    Dutasteride (GG745)是5α 还原酶同工酶 (5α-reductase isozymes) 抑制剂,还可能因其结构域DHT相似对雄激素受体 (AR) 产生脱靶效应。
  • HY-13635
    Finasteride Inhibitor 99.97%
    Finasteride (MK-906) 是一种有效的竞争性 5α-还原酶 (5α-reductase) 抑制剂,对 II 型 5α-还原酶的 IC50 值为 4.2 nM。Finasteride 对 II 型 5α-还原酶的亲和力比对 I 型酶高约 100 倍。Finasteride 可用于研究前列腺增生 (BPH) 和雄激素性脱发。
  • HY-B0141A
    Alpha-Estradiol Inhibitor 99.77%
    Alpha-Estradiol 是一种雌性激素,是 5α-reductase 抑制剂,有潜力用于雄原性脱发的研究。
  • HY-107385
    Epristeride Inhibitor 99.96%
    Epristeride 是一种新型的 5α-还原酶 (5α-reductase) 抑制剂。
  • HY-118091
    LY191704 Inhibitor
    LY191704 作为一种苯并喹啉酮,是一种高效、非甾体、非竞争性和选择性 human type I 5α-reductase 抑制剂。LY191704 是 LY300502 和 LY300503 化合物的外消旋混合物。LY191704 可能有助于研究由 human type I 5α-reductase 产生的二氢睾酮 (DHT) 过多引起的人类内分泌紊乱。
  • HY-N1200
    Stigmasterol glucoside Inhibitor
    Stigmasterol glucoside 是从 P. urinaria 分离出的一种甾醇,具有高抗氧化和高抗炎活性,能作为抑制剂 5α-reductase 的抑制剂,IC50 值为 27.2 µM。
  • HY-N7510
    12-O-Methylcarnosic acid Inhibitor
    12-O-Methylcarnosic acid (12-Methoxycarnosic acid) 是从小叶丹参的丙酮提取物中分离的一种二萜肉桂酸,是 5α-还原酶 (5α-reductase) 抑制的活性成分,IC50 为 61.7 μM。12-O-Methylcarnosic acid 抑制 LNCaP 细胞的增殖。12-O-Methylcarnosic acid 具有抗氧化、抗癌和抗微生物活性。
  • HY-13635A
    Finasteride acetate Inhibitor
    Finasteride (MK-906) acetate 是一种有效的竞争性 5α-还原酶 (5α-reductase) 抑制剂,对 II 型 5α-还原酶的 IC50 值为 4.2 nM。Finasteride acetate 对 II 型 5α-还原酶的亲和力比对 I 型酶高约 100 倍。Finasteride acetate 可用于研究前列腺增生 (BPH) 和雄激素性脱发。
  • HY-U00376
    5α-reductase-IN-1 Inhibitor
    5α-reductase-IN-1 是一种 5α-reductase 抑制剂,可与 minoxidil 混合使用,研究脱发症状。
  • HY-U00125
    CGP-53153 Inhibitor
    CGP-53153是甾体类的 5 alpha reductase 抑制剂,在大鼠和人前列腺组织中的 IC50 值分别为36 nM。
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