1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. 5 alpha Reductase

5 alpha Reductase

5 alpha Reductase (5α-reductases), also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism, and prostate cancer.

5 alpha Reductase 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-13613
    Dutasteride Inhibitor 99.73%
    Dutasteride (GG745)是5α 还原酶同工酶 (5α-reductase isozymes) 抑制剂,还可能因其结构域DHT相似对雄激素受体 (AR) 产生脱靶效应。
  • HY-13635
    Finasteride Inhibitor 99.97%
    Finasteride是口服活性的睾酮5α-还原酶抑制剂,Ki为10 nM。
  • HY-B0141A
    Alpha-Estradiol Inhibitor 99.46%
    Alpha-Estradiol 是一种雌性激素,同时为 5α-reductase 抑制剂,用于局部药物治疗雄原性脱发。
  • HY-107385
    Epristeride Inhibitor 99.96%
    Epristeride 是一种新型的 5α-还原酶 (5α-reductase) 抑制剂。
  • HY-N1200
    Stigmasterol glucoside Inhibitor
    Stigmasterol glucoside 是从 P. urinaria 分离出的一种甾醇,具有高抗氧化和高抗炎活性,能作为抑制剂 5α-reductase 的抑制剂,IC50 值为 27.2 µM。
  • HY-N7510
    12-O-Methylcarnosic acid Inhibitor
    12-O-Methylcarnosic acid (12-Methoxycarnosic acid) 是从小叶丹参的丙酮提取物中分离的一种二萜肉桂酸,是 5α-还原酶 (5α-reductase) 抑制的活性成分,IC50 为 61.7 μM。12-O-Methylcarnosic acid 抑制 LNCaP 细胞的增殖。12-O-Methylcarnosic acid 具有抗氧化、抗癌和抗微生物活性。
  • HY-13635A
    Finasteride acetate Inhibitor
  • HY-U00125
    CGP-53153 Inhibitor
    CGP-53153是甾体类的 5 alpha reductase 抑制剂,在大鼠和人前列腺组织中的 IC50 值分别为36 nM。
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