1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. ATGL

ATGL (脂肪甘油三酯脂肪酶)

Adipose triglyceride lipase

Adipose triglyceride lipase (ATGL) is rate-limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipolysis marks ATGL as interesting pharmacological target since deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders. Here we report on the development and characterization of a small-molecule inhibitor of ATGL. Atglistatin is selective for ATGL and reduces fatty acid mobilization in vitro and in vivo. ATGL performs the first step in triacylglycerol (TG) catabolism generating diacylglycerol which is subsequently degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL) into glycerol and fatty acids (FA).

Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to triacylglycerol (TG) breakdown in in vitro assays and in organ cultures of murine white adipose tissue (WAT).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15859
    Atglistatin Inhibitor 99.57%
    Atglistatin 是一种选择性的脂肪甘油三酯脂酶 (ATGL) 抑制剂,体外抑制脂解作用,IC50 为 0.7 μM。
  • HY-148756
    NG-497 Inhibitor 98.67%
    NG-497 是一种选择性的人类的脂肪甘油三酯脂肪酶 (ATGL) 抑制剂,可以靶向人类 ATGL 的酶促活性 patatin 样结构域。NG-497 对肿瘤研究具有潜在价值。
  • HY-E70277
    Hexadecyl-CoA Inhibitor
    Hexadecyl-CoA 是酰基辅酶 A 的硫醚类似物,能抑制脂肪甘油三酯脂肪酶 (ATGL)。
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