1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. ATGL


Adipose triglyceride lipase (ATGL) is rate-limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipolysis marks ATGL as interesting pharmacological target since deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders. Here we report on the development and characterization of a small-molecule inhibitor of ATGL. Atglistatin is selective for ATGL and reduces fatty acid mobilization in vitro and in vivo. ATGL performs the first step in triacylglycerol (TG) catabolism generating diacylglycerol which is subsequently degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL) into glycerol and fatty acids (FA).

Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to triacylglycerol (TG) breakdown in in vitro assays and in organ cultures of murine white adipose tissue (WAT).

ATGL 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-15859
    Atglistatin Inhibitor 98.06%
    Atglistatin 是一种选择性的脂肪甘油三酯脂酶 (ATGL) 抑制剂,体外抑制脂解作用,IC50 为 0.7 μM。
  • HY-100008
    Peretinoin Activator 98.38%
    Peretinoin 是一种口服非环状类视黄醇,具有类维生素 A 结构,靶向类视黄醇核受体。Peretinoin 通过下调转录因子 Sp1,在体外降低 SPHK1mRNA 水平。 Peretinoin 通过增加 Atg16L1 表达激活自噬途径,防止非酒精性脂肪性肝炎(NASH)和肝细胞癌(HCC)的发展。Peretinoin 通过改变脂质代谢来抑制 HCV RNA 扩增和病毒释放,EC50 为 9 μM。
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