1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. ATP Citrate Lyase

ATP Citrate Lyase

ATP-citrate lyase (ACL) is a cytosolic enzyme upstream of HMG-CoA reductase in the lipid biosynthesis pathway that catalyses the cleavage of mitochondrial-derived citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. Although ACL is not rate limiting, its strategic position at the intersection of lipid and carbohydrate metabolism, and its potential to regulate lipoprotein metabolism, attracted early interest as a drug target to treat dyslipidemia.

ATP-citrate lyase (ACL) is an extramitochondrial enzyme that is expressed in lipogenic tissues such as liver and adipose. Since ACL is the primary enzyme responsible for the production of cytosolic acetyl-CoA, a precursor required for de novo biosyntheses of cholesterol and fatty acids, inhibition of ACL has the potential to reduce cholesterol and triglyceride levels and possibly exert an impact on obesity via reduction of lipogenic factors.

ACL is an important enzyme with significant effects on fatty acid and cholesterol metabolism. It is a cytosolic enzyme highly expressed in lipogenic tissues such as the liver and white adipose tissue and is positioned upstream from HMG-CoA reductase in the mammalian cholesterol biosynthesis pathway. It links energy metabolism from carbohydrates to the production of fatty acids through catalyzing acetyl CoA synthesis, the fundamental substrate for the biosynthesis of both fatty acids and cholesterol.

ATP Citrate Lyase 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-12357
    Bempedoic acid Inhibitor >98.0%
    Bempedoic acid (ETC-1002) 是一种 ATP-柠檬酸裂解酶 (ATP-citrate lyase;ACL) 抑制剂。Bempedoic acid (ETC-1002) 激活 AMPK
  • HY-16107
    BMS-303141 Inhibitor 98.08%
    BMS-303141是高效性和可渗透细胞的 ACL 抑制剂,IC50值为0.13 μM。
  • HY-16450
    SB 204990 Inhibitor 99.50%
    SB 204990是ATP柠檬酸裂解酶 (ACLY) 的有效特异性抑制剂。
  • HY-127111
    NDI-091143 Inhibitor 99.72%
    NDI-091143 是一种有效的高亲和力人 ATP 柠檬酸裂解酶 (ACLY) 抑制剂,IC50 为 2.1 nM (ADP-Glo分析),Ki 为 7.0 nM,Kd 为 2.2 nM。NDI-091143 通过稳定柠檬酸盐域中的大构象变化来间接抑制柠檬酸的结合和识别,从而抑制了 ACLY 催化变构反应。
  • HY-W012946
    2-Furoic acid Inhibitor >98.0%
    2-Furoic acid (Furan-2-carboxylic acid) 是一种有机化合物,经糠醛氧化得到。在大鼠试验中,2-Furoic acid 具有抗血脂作用,能够降低血清中胆固醇和甘油三酯的水平。
  • HY-N7347
    (-)-Hydroxycitric acid lactone Inhibitor
    (-)-Hydroxycitric acid lactone (Garcinia lactone) 是一种减肥药,也是一种很受欢迎的减肥食品补充剂。(-)-Hydroxycitric acid lactone 是一种有效的 ATP-柠檬酸裂解酶 抑制剂。(-)-Hydroxycitric acid lactone 催化柠檬酸盐线粒体外裂解为草酰乙酸和乙酰辅酶 A,限制了脂肪酸合成所需乙酰辅酶 A 单位的可用性。
  • HY-W009156
    Hydroxycitric acid tripotassium hydrate Inhibitor
    Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) 是藤黄果的主要活性成分,也是柠檬酸的衍生物。Hydroxycitric acid tripotassium hydrate 可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ,并具有减肥效果。Hydroxycitric acid tripotassium hydrate 有效抑制结石形成并抑制 HIF,具有抗氧化,抗炎和抗肿瘤作用。
  • HY-16007
    (-)-Hydroxycitric acid Inhibitor
    (-)-Hydroxycitric acid (Garcinia acid) 是 Garcinia cambogia 果皮中的主要酸。(-)-Hydroxycitric acid 是一种有效的竞争性 ATP 柠檬酸裂解酶 (ATP citrate lyase) 抑制剂。(-)-Hydroxycitric acid 可抑制脂肪酸的合成,脂肪生成,食物摄入,并促进体重减轻。
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