1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Adenosine Deaminase

Adenosine Deaminase (腺苷脱氨酶)

Adenosine deaminase (ADA) is an enzyme of the purine metabolism which catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. This ubiquitous enzyme has been found in a wide variety of microorganisms, plants, and invertebrates. In addition, it is present in all mammalian cells that play a central role in the differentiation and maturation of the lymphoid system. Two distinct adenosine deaminases, ADA1 and ADA2, are found in humans. ADA1 has an important role in lymphocyte function and inherited mutations in ADA1 result in severe combined immunodeficiency. ADA2 belongs to the novel family of adenosine deaminase growth factors (ADGFs), which play an important role in tissue development.

ADA plays a critical role in various diseases. Interestingly, Both genetic ADA deficiency and ADA overexpression may cause diseases. Generally appreciated is the notion that inherited genetic ADA deficiency represents the main cause of severe combined immunodeficiency disease (SCID), accounting for about 15% of all SCID cases. Conversely, overexpression of ADA may be closely related to hemolytic anemia, liver cancer, breast cancer, etc.

Adenosine Deaminase 相关产品 (8):

目录号 产品名 作用方式 纯度
  • HY-A0006
    Pentostatin Inhibitor 99.93%
    Pentostatin (CI-825; Deoxycoformycin) 是一种高效,不可逆的腺苷脱氨酶抑制剂,Ki 值为 2.5 pM。
  • HY-13599
    Cladribine Inhibitor 99.97%
    Cladribine (2-Chloro-2′-deoxyadenosine) 是一种嘌呤核苷类似物,是具有口服活性的腺苷脱氨酶 (adenosine deaminase) 抑制剂。Cladribine 能作为 DNA 合成 (DNA synthesis) 的抑制剂,可阻断受损 DNA 的修复。Cladribine 可以抑制 DNA 甲基化。Cladribine 具有抗淋巴瘤活性,可用于一些血液恶性肿瘤和多发性硬化的研究。
  • HY-103160A
    EHNA hydrochloride Inhibitor ≥98.0%
    EHNA hydrochloride 是一个强有力的和选择性的环核苷酸磷酸二酯酶 2 (PDE2) (IC50=4 μM) 和腺苷脱氨酶 (ADA) 的双重抑制剂。EHNA hydrochloride 浓度依耐性抑制 cGMP 刺激的 PDE2 的活性,IC50 值分别为 0.8 μM (人类) 和 2 μM (猪心肌),但是对没有刺激的 PDE2 抑制力较小。EHNA hydrochloride 在调节多种药理反应中发挥作用,包括抗病毒、抗肿瘤和抗心律失常作用。
  • HY-115686
    8-Azaadenosine Inhibitor ≥99.0%
    8-Azaadenosine 是一种有效的 ADAR1 抑制剂。8-Azaadenosine 是一种 A-to-I 编辑抑制剂。8-Azaadenosine 可阻断 RNA 编辑并抑制甲状腺癌细胞的增殖、3D 生长、侵袭和迁移。
  • HY-114175
    Adenosine deaminase
    Adenosine deaminase 是一种酶,可以对腺苷和 2'-脱氧腺苷进行不可逆的脱氨基作用,分别转化为肌苷和 2'-脱氧肌苷。
  • HY-117260
    Coformycin Inhibitor
    Coformycin 是一种核苷类抗生素,是腺苷脱氨酶 (adenosine deaminase , ADA) 的抑制剂。Coformycin 具有抗肿瘤和抗菌活性。
  • HY-103159
    1-Deazaadenosine Inhibitor
    1-Deazaadenosine 是一种有效的腺苷脱氨酶 (ADA) 抑制剂,Ki 值为 0.66 μM。 1-Deazaadenosine 在体外表现出抗癌活性,有潜力作为化疗试剂用于淋巴增生性疾病的研究。
  • HY-N7368
    Hibifolin Inhibitor
    Hibifolin 是一种黄酮醇糖苷,是潜在的腺苷脱氨酶 (ADA) 抑制剂。Hibifolin 可以保护神经元免受 beta-淀粉样蛋白诱导的神经毒性。
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