2. Metabolic Enzyme/Protease Apoptosis
  3. Adenosine Deaminase Apoptosis
  4. ADAR1-IN-1

ADAR1-IN-1 是一种强效的 ADAR1 抑制剂。ADAR1-IN-1 显著抑制了 DU-145 细胞的增殖 (IC50 = 1.11 μM)、克隆形成、迁移和侵袭，并诱导细胞周期阻滞和凋亡(apoptosis)。ADAR1-IN-1 能安全有效地抑制肿瘤生长。ADAR1-IN-1 可用于前列腺癌 (PCa) 的研究[1]。。

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ADAR1-IN-1

ADAR1-IN-1 Chemical Structure

CAS No. : 2734853-87-1

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ADAR1-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ADAR1-IN-1 is a potent ADAR1 inhibitor. ADAR1-IN-1 significantly suppressed DU-145 cell proliferation (IC50 = 1.11 μM), clonogenicity, migration, and invasion, arrests cell cycle, and induces apoptosis. ADAR1-IN-1 safely and effectively inhibits tumor growth. ADAR1-IN-1 can be used for the study of prostate cancer (PCa)[1].

体外研究
(In Vitro)

ADAR1-IN-1 (Compound C12) (1-3 μM, 1-10 days) 在 1 μM 浓度下显著抑制 DU-145 细胞的生长和集落形成，在 3 μM 时观察到最大抑制作用[1]。
ADAR1-IN-1 (1-3 μM, 24 h) 呈剂量依赖性地抑制 DU-145 细胞的迁移和侵袭[1]。
ADAR1-IN-1 (1-3 μM, 24 h) 可将 DU-145 细胞阻滞在 G0/G1 期，并呈剂量依赖性地诱导凋亡[1]。
ADAR1-IN-1 (1-3 μM, 48 h) 降低了 N-钙黏蛋白和波形蛋白的表达量，而增加了 p53 的表达量[1]。
ADAR1-IN-1 (72 h) 对雄激素受体依赖性 VCaP 细胞、去势抵抗性 22Rv1 细胞和 AR 阴性 PC-3 细胞表现出显著的增殖抑制作用，IC50 值分别为 1.76 μM、1.79 μM 和 0.72 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ADAR1-IN-1 相关抗体:

Cell Migration Assay [1]

Cell Line: DU-145 cells
Concentration: 1, 2 and 3 μM
Incubation Time: 24 h
Result: Dose-dependently inhibited the migration.

Cell Cycle Analysis[1]

Cell Line: DU-145 cells
Concentration: 1, 2 and 3 μM
Incubation Time: 24 h
Result: Arrested cells in the G0/G1 phase.

Apoptosis Analysis[1]

Cell Line: DU-145 cells
Concentration: 1, 2 and 3 μM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: DU-145 cells
Concentration: 1, 2 and 3 μM
Incubation Time: 48 h
Result: Induced a concentration-dependent downregulation of N-cadherin and vimentin. Decreased CDk6 and c-MYC, and increased p53.
体内研究
(In Vivo)

ADAR1-IN-1 (Compound C12) (15-30 mg/kg, i.p. 每天两次共 19 天) 在 DU-145 和 22Rv1 肿瘤移植小鼠模型中，具有显著的抗肿瘤效果和良好的安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DU-145 and 22Rv1 xenograft models established in male BALB/c nude mice[1]
Dosage: 15 and 30 mg/kg
Administration: Intraperitoneal injection (i.p.), twice daily for 19 days
Result: Significantly inhibited tumor growth with tumor growth inhibition (TGI) rates of 41.8% and 52.8%, respectively in DU-145 model and 46.4% and 59.0%, respectively in 22Rv1 model.
No obvious lesions were observed in the main organs of the mice.
分子量

493.39

Formula

C17H15F4N5O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ADAR1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADAR1-IN-12734853-87-1Adenosine DeaminaseApoptosisNucleoside analogsProstate cancerDU-145 cells22Rv1 cellsXenograft modelInhibitorinhibitorinhibit

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