1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. Adrenergic Receptor

Adrenergic Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor 相关产品 (195):

Cat. No. Product Name Effect Purity
  • HY-B0468
    Isoprenaline hydrochloride Agonist >99.0%
    Isoprenaline hydrochloride是一种非选择性的β-肾上腺素能受体激动剂,具有有效的外周血管扩张剂,支气管扩张剂和心脏刺激活性。
  • HY-13715B
    Norepinephrine bitartrate monohydrate Agonist 99.75%
    Norepinephrine bitartrate monohydrate (Levarterenol bitartrate monohydrate) 是β1-选择性的肾上腺素能受体激动剂,EC50 为 5.37 μM。
  • HY-13951
    ICI 118,551 hydrochloride Antagonist 98.50%
    ICI 118,551 hydrochloride 是一种高度选择性的 β2 adrenergic receptor 拮抗剂,结合 β2,β1 和 β3 肾上腺素能受体的Ki 值分别为 0.7,49.5 和 611 nM。
  • HY-B0573
    Propranolol hydrochloride Antagonist 99.92%
    Propranolol hydrochloride 是一种非选择性的 β-adrenergic receptor (βAR) 拮抗剂,对 β1AR 和 β2AR 具有高亲和力,Ki 值分别为 1.8 nM 和 0.8 nM。Propranolol hydrochloride 抑制 [3H]-DHA 与大鼠脑膜制剂的结合,IC50 为 12 nM。Propranolol hydrochloride 用于控制高血压,嗜铬细胞瘤,心肌梗塞,心律不齐,心绞痛和肥大心肌病。
  • HY-B0471
    (R)-(-)-Phenylephrine hydrochloride Agonist 98.10%
    (R)-(-)-Phenylephrine hydrochloride是一种选择性的α1-肾上腺素能受体激动剂,对α1D,α1B 和α1A 受体的pKis 分为5.86,4.87和4.70。
  • HY-121251
    BI-167107 Agonist 99.81%
    BI-167107 是一种高亲和力的 β2 肾上腺素能受体 (β2AR) 完全激动剂,与 β2 肾上腺素能受体 (β2AR) 结合,解离常数 Kd 为 84 pM。
  • HY-101325
    BRL 37344 sodium Agonist
    BRL 37344 sodium (BRL 37344A) 是特异性 β3-肾上腺素能受体 (β3-adrenergic receptor) 激动剂。 BRL 37344 sodium 治疗显着降低了肥胖小鼠的体重。
  • HY-101514
    β3-AR agonist 1 Agonist
    β3-AR agonist 1 (compound 15) 是一种高效选择性的,可口服的 β3-肾上腺素能受体 (β3-AR) 激动剂 (EC50=18 nM),对 β1-、β2-、α1A-AR 无活性 (β1/β3, β2/β3, α1A/β3>556倍)。
  • HY-14773
    Mirabegron Agonist 99.08%
    Mirabegron 是一种选择性的肾上腺素受体 (β3-adrenoceptor) 激动剂,EC50 为 22.4 nM。
  • HY-B0447B
    L-Epinephrine Agonist >99.0%
    L-Epinephrine是由肾上腺髓质分泌的激素。它是α-adrenergicβ-adrenergic受体激动剂。
  • HY-N0127
    Yohimbine Hydrochloride Antagonist 99.85%
    Yohimbine Hydrochloride 是 α-2肾上腺素能受体抑制剂,阻断突触前或突触后的 α-2肾上腺素能受体,引起去甲肾上腺素和多巴胺的释放。
  • HY-B0006
    Carvedilol Inhibitor 99.93%
    Carvedilol(BM14190)是非选择性β和α1阻断剂,能抑制LDL的氧化,IC50为3.8 μM。
  • HY-B0193A
    Prazosin hydrochloride Antagonist 99.73%
    Prazosin 盐酸盐是 α 肾上腺素阻断剂,可作用于高血压、焦虑和恐慌症等。
  • HY-17498
    Atenolol Antagonist >98.0%
    Atenolol是选择性β1肾上腺素受体拮抗剂。
  • HY-12987
    Pimozide Antagonist 99.88%
    Pimozide 是 dopamine receptor 的拮抗剂,对 dopamine D2,D3 和 D1 受体的 Ki 值分别为 1.4 nM,2.5 nM 和 588 nM,同时对 α1-adrenoceptor 也有较高亲和性,Ki 值为 39 nM;Pimozide 也是 STAT3STAT5 的抑制剂。
  • HY-B0162A
    Ivabradine hydrochloride Inhibitor 98.39%
    Ivabradine hydrochloride 是可口服的,超极化激活的环核苷酸门控离子通道 (HCN) 通道阻滞剂。
  • HY-B0447A
    L-Epinephrine Bitartrate Agonist >99.0%
    L-Epinephrine bitartrate ((-)-Epinephrine (+)-bitartrate salt) 是 α-adrenergicβ-adrenergic 的激动剂。L-Epinephrine bitartrate ((-)-Epinephrine (+)-bitartrate salt) 是由肾上腺髓质分泌的激素。
  • HY-B0437
    Sotalol hydrochloride Antagonist 99.77%
    Sotalol 盐酸盐 (MJ-1999) 是肾上腺素受体拮抗剂,可作用于威胁生命的心律失常。
  • HY-B0362A
    Phentolamine mesylate Antagonist 99.83%
    Phentolamine mesylate是竞争性,可逆的 α-肾上腺素能受体 拮抗剂,IC50 在5和30 nM之间。
  • HY-B0443A
    Xylazine hydrochloride Agonist 99.90%
    Xylazine hydrochloride (BAY 1470 hydrochloride) 是一种高效的 α2-adrenergic 激动剂,在兽医学中用作镇静剂,镇痛剂和肌肉松弛剂。
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