1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Aurora Kinase

Aurora Kinase

Aurora kinases are serine/threonine kinases that are essential for cell proliferation. Aurora kinase helps the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. Three Aurora kinases have been identified in mammalian cells to date, Aurora A, Aurora B, Aurora C. Besides being implicated as mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated expression profiles in many human cancers. The human Aurora kinases present a similar domain organization, with a N-terminal domain of 39 to 129 residues in length, a protein kinase domain and a short C-terminal domain containing 15 to 20 residues. The N-terminal domain of three proteins share low sequence conservation, which determines selectivity during protein-protein interactions.

Aurora Kinase Isoform Specific Products:

  • Aurora A

  • Aurora B

  • Aurora C

Aurora Kinase 相关产品 (41):

Cat. No. Product Name Effect Purity
  • HY-10971
    Alisertib Inhibitor 99.84%
    Aliertib (MLN 8237) 是一种口服活性和选择性的 Aurora A 激酶抑制剂 (IC50=1.2 nM),与Aurora A 激酶结合,导致有丝分裂纺锤体异常、有丝分裂累积。Aliertib (MLN 8237) 通过靶向白血病细胞中的 AKT/mTOR/AMPK/p38 途径诱导其凋亡和自噬。具有抗肿瘤活性。
  • HY-10126
    Barasertib-HQPA Inhibitor 99.47%
    Barasertib-HQPA (AZD2811) 是一种高度选择性的极光激酶B抑制剂,在非细胞试验中 IC50 值为0.37 nM。Barasertib-HQPA (AZD2811) 对Aurora B 的选择性是Aurora A的3700倍。
  • HY-114258
    LY3295668 Inhibitor 99.61%
    LY3295668 (AK-01) 是高度特异性的 Aurora-A kinase 的抑制剂,其对 AurA 和 AurB 的Ki 值分别为 0.8 nM 和 1038 nM。
  • HY-10161
    Tozasertib Inhibitor 99.85%
    Tozasertib (VX 680; MK-0457) 是 Aurora A/B/C 激酶抑制剂,Ki 值分别为 0.6,18,4.6 nM。
  • HY-10179
    Danusertib Inhibitor 99.44%
    Danusertib 是一种极光激酶 (aurora kinase) 抑制剂,能够抑制 Aurora A,Aurora B 和 Aurora C 的活性,IC50 值分别为 13,79 和 61 nM。
  • HY-10032
    PF 477736 Inhibitor 99.21%
    PF 477736 (PF 00477736) 是一种有效,选择性和 ATP 竞争性的 Chk1 的抑制剂,Ki 值为 0.49 nM。它也是 Chk2 抑制剂,Ki 值为 47 nM。PF 477736 显示出对 VEGFR2FmsYesAurora-AFGFR3Flt3Ret (IC50=8 (Ki),10,14,23,23,25 和 39 nM) <100 倍的选择性。PF 477736 在体外和体内均可增强 Gemcitabine 的抗肿瘤活性。
  • HY-10482
    SCH-1473759 Inhibitor 98.20%
    SCH-1473759是多靶点的的极光激酶 (aurora) 抑制剂,对极光激酶A和B的IC50 值分别为4 和13 nM。
  • HY-12054A
    Hesperadin hydrochloride Inhibitor
    Hesperadin hydrochloride 是 Aurora AB 的 ATP 竞争性吲哚酮抑制剂。Hesperadin hydrochloride 以 250 nM 的 IC50 抑制 Aurora B。
  • HY-13252
    MK-5108 Inhibitor >98.0%
    MK-5108是高效和特异性的极光激酶A抑制剂,IC50 值为0.064 nM。
  • HY-50514
    AT9283 Inhibitor 99.61%
    AT9283 是一种多靶点激酶抑制剂,有效抑制 Aurora A/BJAK2/3Abl (T315I),和 Flt3 (IC50 值范围为 1-30 nM)。AT9283 抑制多种实体瘤在体内外的生长和存活。
  • HY-10127
    AZD1152 Inhibitor 99.62%
    AZD1152 是 Barasertib-hQPA 的前体药物,是高度选择性的 Aurora B 抑制剂,IC50 值为 0.37 nM。
  • HY-10329
    JNJ-7706621 Inhibitor 99.91%
    JNJ-7706621 是一种有效的 aurora kinase 抑制剂,同时能有效抑制 CDK1CDK2,对 CDK1CDK2aurora-Aaurora-BIC50 值分别为 9 nM,3 nM,11 nM 和 15 nM。
  • HY-70044
    GSK-1070916 Inhibitor 99.55%
    GSK-1070916是有效,选择性,ATP竞争型的极光激酶B/C (aurora B/C) 抑制剂,Ki 值分别为0.38和1.5 nM。
  • HY-14574
    PF-03814735 Inhibitor 99.77%
    PF-03814735是有效,有口服性,可逆的极光激酶A和B (aurora A/B) 的抑制剂,IC50值分别为0.8和5 nM。
  • HY-10339
    KW-2449 Inhibitor 99.85%
    KW-2449是多靶点激酶抑制剂,对FLT3ABLABLT315IAurora kinaseIC50 值分别为6.6,14,4 和 48 nM。
  • HY-13253
    AMG 900 Inhibitor 98.19%
    AMG 900 是一种有效的选择性的 pan-Aurora 激酶抑制剂,作用于 Aurora ABCIC50 分别为 5 nM,4 nM 和 1 nM。
  • HY-12003
    SNS-314 Inhibitor 99.90%
    SNS-314有效,选择性的极光激酶 (aurora) 抑制剂,对极光激酶A,B,C的IC50 值分别为9,31 和6 nM。
  • HY-14711
    Reversine Inhibitor 99.40%
    Reversine 是一种ATP-竞争性的 Aurora kinase 抑制剂,作用于 Aurora AAurora BAurora CIC50 分别为 400,500 和 400 nM。
  • HY-10558
    CYC-116 Inhibitor 98.17%
    CYC-116是有效的极光激酶A和B (aurora A/B) 的抑制剂,Ki 值分别为8和9 nM。
  • HY-15767
    TAK-632 Inhibitor 99.13%
    TAK-632 是一种有效的 pan-RAF 抑制剂,作用于 CRAFBRAFV600EBRAFWTIC50 分别为 1.4,2.4 和 8.3 nM。
Isoform Specific Products

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