1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Aurora Kinase

Aurora Kinase (极光激酶)

The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C). Aurora kinases control multiple events during cell cycle progression and are essential for mitotic and meiotic bipolar spindle assembly and function.

Aurora-A, Aurora-B, and Aurora-C share a highly conserved kinase domain but have quite different subcellular localizations and functions during mitosis. Aurora-A mostly controls centrosome maturation and bipolar spindle assembly, while Aurora-B and Aurora-C are required for condensation, attachment to kinetochores, and alignment of chromosomes during (pro-)metaphase and cytokinesis. In human tumors, all Aurora kinase members play oncogenic roles related to their mitotic activity and promote cancer cell survival and proliferation. Inhibitors targeting Aurora kinases have attracted attention in cancer research.

Aurora Kinase 亚型特异性产品:

  • Aurora A

  • Aurora B

  • Aurora C

Aurora Kinase 相关产品 (13):

目录号 产品名 作用方式 纯度
  • HY-50514
    AT9283 Inhibitor 99.61%
    AT9283 是一种多靶点激酶抑制剂,有效抑制 Aurora A/BJAK2/3Abl (T315I),和 Flt3 (IC50 值范围为 1-30 nM)。AT9283 抑制多种实体瘤在体内外的生长和存活。
  • HY-10339
    KW-2449 Inhibitor 99.85%
    KW-2449是多靶点激酶抑制剂,对FLT3ABLABLT315IAurora kinaseIC50 值分别为6.6,14,4 和 48 nM。
  • HY-14574
    PF-03814735 Inhibitor 99.82%
    PF-03814735是有效,有口服性,ATP 竞争性的,可逆的极光激酶A和B (aurora A/B) 的抑制剂,IC50值分别为0.8和5 nM。
  • HY-10128
    ZM-447439 Inhibitor 99.19%
    ZM-447439是极光激酶 (aurora) 抑制剂,对aurora A和B的 IC50 值分别为110和130 nM。
  • HY-12003
    SNS-314 mesylate Inhibitor 99.90%
    SNS-314 mesylate 是一种有效的选择性极光激酶 (aurora) 抑制剂,对极光激酶 A,B,C 的IC50 值分别为 9,31 和 6 nM。
  • HY-112355
    Aurora kinase inhibitor-2 Inhibitor 99.19%
    Aurora kinase inhibitor-2 是一种选择性和 ATP 竞争性的 Aurora 激酶抑制剂,对 Aurora AAurora BIC50 分别为 310 nM 和 240 nM。
  • HY-10483
    SCH-1473759 hydrochloride Inhibitor 99.79%
    SCH-1473759 hydrochloride是多靶点的的极光激酶 (aurora) 抑制剂,对极光激酶A和B的IC50 值分别为4 和13 nM。
  • HY-10804
    CCT 137690 Inhibitor 99.10%
    CCT 137690是有效的,有口服活性的极光激酶 (aurora) 抑制剂,对极光激酶A,B,C的 IC50 值分别为15,25 和19 nM。
  • HY-107419
    NU6140 Inhibitor ≥99.0%
    NU6140 是一种选择性的 CDK2-cyclin A 抑制剂 (IC50,0.41 μM),对其选择性是对其他 CDK 的 10-36 倍。NU6140 有效抑制 Aurora AAurora B 的活性,IC50 值分别为 67 和 35 nM。增强诱导凋亡的作用,抗肿瘤作用。
  • HY-10482
    SCH-1473759 Inhibitor 98.20%
    SCH-1473759是多靶点的的极光激酶 (aurora) 抑制剂,对极光激酶A和B的IC50 值分别为4 和13 nM。
  • HY-124330
    Tripolin A Inhibitor
    Tripolin A ((E)-Tripolin A) 是特异性的,非ATP 竞争性的 Aurora A 激酶抑制剂,其对Aurora A 和Aurora B 的 IC50 分别为1.5 μM 和7 μM。
  • HY-111506
    Aurora inhibitor 1 Inhibitor
    Aurora inhibitor 1 是一种有效的 Aurora 抑制剂,抑制 Aurora AAurora B 激酶的 IC50 分别 ≤4 nM 和 ≤13 nM。
  • HY-U00304
    Aurora B inhibitor 1 Inhibitor
    Aurora B inhibitor 1 是一种 Aurora B (Aurora-1) 抑制剂,Ki 值 <0.010 uM。详细信息请参考专利文献 WO2007059299A1 中的化合物 1-3。
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